bModelTest: Bayesian phylogenetic site model averaging and model comparison

BMC Evolutionary Biology

Software

Alexei J. Drummond¹  Remco R. Bouckaert² 

[1] Centre for Computational Evolution, University of Auckland, Auckland, New Zealand;Department of Computer Science, University of Auckland, Auckland, New Zealand;Centre for Computational Evolution, University of Auckland, Auckland, New Zealand;Department of Computer Science, University of Auckland, Auckland, New Zealand;Max Planck Institute for the Science of Human History, Jena, Germany;

关键词: Model averaging;    Model selection;    Model comparison;    Statistical phylogenetics;    ModelTest;    Phylogenetic model averaging;    Phylogenetic model comparison;    Substitution model;    Site model;   

DOI  :  10.1186/s12862-017-0890-6

 received in 2016-06-19, accepted in 2017-01-19,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundReconstructing phylogenies through Bayesian methods has many benefits, which include providing a mathematically sound framework, providing realistic estimates of uncertainty and being able to incorporate different sources of information based on formal principles. Bayesian phylogenetic analyses are popular for interpreting nucleotide sequence data, however for such studies one needs to specify a site model and associated substitution model. Often, the parameters of the site model is of no interest and an ad-hoc or additional likelihood based analysis is used to select a single site model.ResultsbModelTest allows for a Bayesian approach to inferring and marginalizing site models in a phylogenetic analysis. It is based on trans-dimensional Markov chain Monte Carlo (MCMC) proposals that allow switching between substitution models as well as estimating the posterior probability for gamma-distributed rate heterogeneity, a proportion of invariable sites and unequal base frequencies. The model can be used with the full set of time-reversible models on nucleotides, but we also introduce and demonstrate the use of two subsets of time-reversible substitution models.ConclusionWith the new method the site model can be inferred (and marginalized) during the MCMC analysis and does not need to be pre-determined, as is now often the case in practice, by likelihood-based methods. The method is implemented in the bModelTest package of the popular BEAST 2 software, which is open source, licensed under the GNU Lesser General Public License and allows joint site model and tree inference under a wide range of models.

【 授权许可】

CC BY   
© The Author(s) 2017

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