Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty

BMC Pediatrics

Research Article

Katre Maasalu¹  Evelin Lätt²  Donvina Vaitkeviciute²  Toivo Jürimäe²  Jarek Mäestu²  Meeli Saar²  Priit Purge²  Jaak Jürimäe³ 

[1] Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia;Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia;Institute of Sport Sciences and Physiotherapy, Centre of Behavioural, Social and Health Science, Faculty of Medicine, University of Tartu, Tartu, Estonia;Institute of Sport Pedagogy and Coaching Sciences, Centre of Behavioral, Social and Health Sciences, University of Tartu, 5 Jakobi Street, 51014, Tartu, Estonia;

关键词: Longitudinal analysis;    Pubertal boys;    Bone turnover;    Adipokines;    Physical activity;   

DOI  :  10.1186/s12887-016-0647-1

 received in 2015-11-26, accepted in 2016-07-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundWe investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys.MethodsNinety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.ResultsOC had a strong longitudinal inverse effect on changes in WB_BMD (p < 0.001) and LS_BMD (p = 0.021), while CTX had an inverse effect only on changes in FN_BMD (p = 0.011). Leptin had an inverse effect on changes in WB_BMC/WB_BMD (p = 0.001), FN_BMD (p = 0.002) and LS_BMD (p = 0.001). MVPA showed a longitudinal inverse effect on changes in leptin (p = 0.030), however no longitudinal effect of SED to biochemical markers of bone and adipose tissue was found.ConclusionsBone metabolism markers have negative effect on bone mineral accrual during puberty. Increases in MVPA affect leptin, suggesting a positive link of MVPA through leptin metabolism on increases in bone mineralization during puberty.

【 授权许可】

CC BY   
© The Author(s). 2016