Anthelmintic activity of silver-extract nanoparticles synthesized from the combination of silver nanoparticles and M. charantia fruit extract

BMC Complementary and Alternative Medicine

Research Article

Fataha Nur Robel¹  Md. Rabiul Islam²  A.H.M. Mazbah Uddin³  Jannatul Ferdous³  Sujan Banik³  Md. Mamun Or Rashid³ 

[1] Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Sonapur, 3814, Noakhali, Bangladesh;Department of Pharmacy, International Islamic University Chittagong, Chandgaon R/A, Chittagong, Bangladesh;Department of Pharmacy, Noakhali Science and Technology University, Sonapur, 3814, Noakhali, Bangladesh;

关键词: Silver Nanoparticles (AgNPs);    Ag-Extract nanoparticles;    M. charantia;    Anthelmintic activity;   

DOI  :  10.1186/s12906-016-1219-5

 received in 2015-12-04, accepted in 2016-07-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPresent study has been conducted to know the anthelmintic activity of polyaniline coated silver nanoparticles (AgNPs) synthesized from Momordica charantia fruit extract.MethodsBy reduction of AgNO3 in presence of NaBH4, silver nanoparticles were prepared. After mixing silver nanoparticles and extracts, coating was given on nanoparticles using polyaniline. Prepared nanoparticles were characterized by Visual, UV, FTIR spectroscopy, SEM techniques, and TEM analysis.ResultsThe FTIR results implied that AgNPs were successfully synthesized and capped with bio-compounds present in the extract. The result showed that death times of worm were 35.12 ± 0.5 and 59.3 ± 0.3 minutes for M. charantia extract and Ag-nanoparticles individually. But when these two combined together, paralysis and death time fall drastically which were only 6.16 ± 0.6 and 9.1 ± 0.4 minutes respectively. Albendazole tablet was used as standard, which made worms death in 3.66 ± 0.1 minutes.ConclusionAg-Extract NPs showed strong anthelmintic activity against worm. This study has paved the way for further research to design new anthelmintic drug from the combination of M. charantia and AgNPs.

【 授权许可】

CC BY   
© The Author(s). 2016