Relationship between pulmonary exacerbations and daily physical activity in adults with cystic fibrosis

BMC Pulmonary Medicine

Research Article

Diana Bilton¹  Nicholas Simmonds²  Serena Quattrucci³  Daniela Savi⁴  Marcello Di Paolo⁵  Paolo Palange⁶  Nicholas S. Hopkinson⁷  Winston Banya⁷ 

[1] Department of Cystic Fibrosis, Royal Brompton Hospital and Imperial College, SW3 6NP, London, UK;Department of Cystic Fibrosis, Royal Brompton Hospital and Imperial College, SW3 6NP, London, UK;NIHR Respiratory BRU, Royal Brompton Hospital NHS Foundation Trust, SW3 6NP, London, UK;Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Sapienza University of Rome, Viale Regina Elena, 324-00185, Rome, Italy;Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Sapienza University of Rome, Viale Regina Elena, 324-00185, Rome, Italy;Department of Cystic Fibrosis, Royal Brompton Hospital and Imperial College, SW3 6NP, London, UK;Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185, Rome, Italy;Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185, Rome, Italy;Eleonora Lorrillard-Spencer Cenci Foundation, 00185, Rome, Italy;NIHR Respiratory BRU, Royal Brompton Hospital NHS Foundation Trust, SW3 6NP, London, UK;

关键词: Daily physical activity;    Pulmonary exacerbation rates;    Cystic fibrosis;    Gender difference;   

DOI  :  10.1186/s12890-015-0151-7

 received in 2015-05-20, accepted in 2015-11-24,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to examine the relationship between pulmonary exacerbations and physical activity (PA) in adults with cystic fibrosis (CF).MethodsWe grouped adults with CF according to their exacerbation status in the year before study enrolment: (1) <1 exacerbation/year; (2) 1–2 exacerbations/year; and (3) >2 exacerbations/year. PA was assessed objectively by means of an accelerometer at the time of study enrolment.ResultsPatients with >2 exacerbations/year spent less time in PA; specifically, fewer activities of mild intensity [>3 metabolic equivalents (METs)], and lower active energy expenditure (P = 0.01 and P = 0.03, respectively). After correcting for relevant confounders, PA levels were not related to the exacerbation frequency in the preceding year. PA at moderate intensity (4.8–7.2 METs) or greater (>7.2 METs) was independently associated with gender and FEV1 % predicted (P = 0.007 and P = 0.04, respectively). Compared with men, women had reduced vigorous activities (P = 0.01) and active energy expenditure (P = 0.01).ConclusionsAdult CF patients with more pulmonary exacerbations in the preceding year have more advanced disease and are less active than their peers. PA was independently associated with gender and airflow obstruction. Gender differences in PA are evident in CF adults.

【 授权许可】

CC BY   
© Savi et al. 2015