Treatment patterns and characteristics of European patients with castration-resistant prostate cancer

BMC Urology

Research Article

Alex Rider¹  Andrew Worsfold¹  Edwina S Baskin-Bey²  Mark Watson²  Bertrand Tombal³  Cora N Sternberg⁴ 

[1] Adelphi Real World, Macclesfield, UK;Astellas Pharma Europe, Leiden, The Netherlands;Cliniques universitaires Saint-Luc UCL, Institut de Recherche Clinique, Université catholique de Louvain, Brussels, Belgium;San Camillo and Forlanini Hospitals, Rome, Italy;Department of Medical Oncology, San Camillo Forlanini Hospital, Padiglione Flajani, 1st floor, Circonvallazione Gianicolense 87, 00152, Rome, Italy;

关键词: Castrate-resistant prostate cancer;    CRPC;    treatment;    hormonal therapy;    Anti-androgen;    LHRH;    Chemotherapy;    Survey;   

DOI  :  10.1186/1471-2490-13-58

 received in 2013-03-20, accepted in 2013-10-30,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundEuropean treatment guidelines recommend the use of hormonal therapy for the treatment of advanced prostate cancer, including castration-resistant prostate cancer (CRPC), but there is little understanding of how common practices in prostate cancer treatment compare across Europe. The aim of this analysis was to evaluate the management of CRPC patients across five European countries (France, Germany, Italy, Spain and the UK).MethodsData were drawn from the Adelphi Real World Prostate Cancer Disease Specific Programme (DSP), a cross-sectional survey of patients undertaken between December 2009 and May 2010. The study is based on physician interviews, physician-completed detailed patient record forms, and a patient-completed questionnaire.ResultsA total of 348 physicians (191 urologists and 157 oncologists) reported on 3477 patients with prostate cancer. Of the 3477 patients, 1405 (40%) were categorised as having CRPC, and 1119 of these had metastatic CRPC. Bone metastases were the most common (78%), followed by liver (37%) and lung (30%). The mean age of CRPC patients was 71 years, 35% were current or ex-smokers and 10% had a family history of prostate cancer. CRPC patients had a mean of 1.8 comorbidities; 66% had hypertension and 32% had diabetes. Most physicians estimated their patients would stop responding to initial hormone therapy after 19–24 months. Overall, addition of an anti-androgen to a luteinising-hormone-releasing hormone (LHRH) agonist was the most commonly prescribed therapy when patients failed initial LHRH agonist therapy, although there were considerable variations between countries. While 72% of physicians in Europe would choose chemotherapy as the next treatment option after diagnosis of CRPC, 31% of this group would initially prescribe this without an LHRH agonist.ConclusionsResults from this analysis highlight inconsistencies in common hormonal therapy treatment patterns for CRPC and hormonal therapy across the EU.

【 授权许可】

CC BY   
© Sternberg et al.; licensee BioMed Central Ltd. 2013