Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study

BMC Pulmonary Medicine

Research Article

Soon Ho Yoon¹  Soo Jung Kim²  Jinwoo Lee³  Sun Mi Choi³  Chang-Hoon Lee³  Jae-Joon Yim³  Sung Koo Han³ 

[1] Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea;Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea;Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-Ro, 110-744, Seoul, Jongno-Gu, Republic of Korea;

关键词: Abdominal fat;    Anthropometry;    Body composition;    Nontuberculous mycobacteria;   

DOI  :  10.1186/s12890-016-0349-3

 received in 2016-07-25, accepted in 2016-12-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundPatients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition.MethodsData from patients with NTM-LD who participated in NTM cohort which started in 1 July 2011 were analyzed. Patients with more than 6 months of follow up were included for analysis. NTM-LD progression was defined as clinician-initiated anti-NTM treatment, based on symptomatic and radiologic aggravation. Body morphotype and composition was measured at entry to the cohort using bioelectrical impedance analysis.ResultsNTM-LD progressed in 47 out of 150 patients with more than 6 months of follow up. Patients with middle (adjusted hazard ratio [aHR], 2.758; 95% confidence interval [CI], 1.112–6.843) or lowest tertile (aHR, 3.084; 95% CI, 1.241–7.668) of abdominal fat ratio had a higher risk of disease progression compared with the highest tertile. Other predictors for disease progression were presence of cavity on chest computed tomography (aHR, 4.577; 95% CI, 2.364–8.861), and serum albumin level <3.5 g/dL (aHR, 12.943; 95% CI, 2.588–64.718).ConclusionsProgression of NTM-LD is associated with body composition. Lower abdominal fat ratio is an independent predictor of NTM-LD progression.Trial registrationClinicalTrials.gov, NCT01616745 Registered 25 March 2012

【 授权许可】

CC BY   
© The Author(s). 2017