Interbirth interval and history of previous preeclampsia: a case–control study among multiparous women

BMC Pregnancy and Childbirth

Research Article

Varduhi Petrosyan¹  Arusyak Harutyunyan¹  Haroutune Armenian² 

[1] American University of Armenia, College of Health Sciences, Baghramyan 40, Yerevan, Armenia;Department of Epidemiology, University of California, Fielding School of Public Health, Los Angeles, USA;American University of Armenia, College of Health Sciences, Baghramyan 40, Yerevan, Armenia;

关键词: Preeclampsia;    Maternity Hospital;    Multiparous Woman;    Household Monthly Income;    Interbirth Interval;   

DOI  :  10.1186/1471-2393-13-244

 received in 2012-11-15, accepted in 2013-12-19,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundPreeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our study were to determine the association of long interbirth interval (IBI) and preeclampsia and to investigate the interactions between long IBI and other risk factors among multiparous women in Yerevan, Armenia.MethodsWe conducted a hospital-based case–control study among 36 multiparous women with preeclampsia (cases) and 148 without preeclampsia (controls) during their last pregnancy, selected from the two largest maternity hospitals in Armenia. The data were collected through telephone-based structured interviews and analyzed using STATA software. The study applied univariate and multivariate logistic regression analyses.ResultsThe study found a significant interaction between IBI and previous history of preeclampsia. Among women without a history of previous preeclampsia, the odds of having preeclampsia among women with long IBI (greater than or equal to five years) was 6.88 time higher compared to those with short IBI (CI: 1.75-27.05; p = 0.006) after adjusting for confounders; among women with a history of previous preeclampsia the odds ratio was 0.60 (CI: 0.07-4.99; p = 0.638). The final fitted model for preeclampsia among multiparous women who had planned their pregnancies included IBI, time to pregnancy, Body Mass Index, method of contraception and household monthly income.ConclusionsLong IBI appeared to be a strong risk factor for preeclampsia development only among women without a history of previous preeclampsia. This finding may contribute to a new approach in understanding the etiology of preeclampsia and may be useful for developing further recommendations for this particular subgroup of women that are at higher risk for preeclampsia development in subsequent pregnancies.

【 授权许可】

CC BY   
© Harutyunyan et al.; licensee BioMed Central Ltd. 2013