A pragmatic randomised multi-centre trial of multifamily and single family therapy for adolescent anorexia nervosa

BMC Psychiatry

Research Article

Mark Berelowitz¹  Mima Simic²  Gladys Ellis²  Irene Yi³  Sabine Landau⁴  John Hodsoll⁴  Ulrike Schmidt⁵  Janet Treasure⁵  Ivan Eisler⁶  Pippa Hugo⁷  Eia Asen⁸  Frances Connan⁹ 

[1] Child and Adolescent Eating Disorders Service, Royal Free Hospital London, NHS Foundation Trust, London, UK;Child and Adolescent Eating Disorders Service, South London and Maudsley NHS Foundation Trust, London, UK;Child and Adolescent Mental Health Service, Surrey and Borders Partnership NHS Foundation Trust, Frimley, UK;Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, London, UK;Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, London, UK;Adult Eating Disorders Service, South London and Maudsley NHS Foundation Trust, London, UK;Institute of Psychiatry, Psychology and Neuroscience, King’s College, London, London, UK;Child and Adolescent Eating Disorders Service, South London and Maudsley NHS Foundation Trust, London, UK;St George’s, University of London, London, UK;University College London, London, UK;Marlborough Family Service, Central and North West London NHS Foundation Trust, London, UK;Vincent Square Eating Disorders Service, Central and North West London NHS Foundation Trust, University of London, London, UK;

关键词: Anorexia nervosa;    Adolescents;    Family therapy;    Multi-family therapy;    Randomised controlled trial;   

DOI  :  10.1186/s12888-016-1129-6

 received in 2016-03-16, accepted in 2016-11-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundConsiderable progress has been made in recent years in developing effective treatments for child and adolescent anorexia nervosa, with a general consensus in the field that eating disorders focussed family therapy (often referred to as Maudsley Family Therapy or Family Based Treatment) currently offers the most promising outcomes. Nevertheless, a significant number do not respond well and additional treatment developments are needed to improve outcomes. Multifamily therapy is a promising treatment that has attracted considerable interest and we report the results of the first randomised controlled trial of multifamily therapy for adolescent anorexia nervosa.MethodsThe study was a pragmatic multicentre randomised controlled superiority trial comparing two outpatient eating disorder focussed family interventions - multifamily therapy (MFT-AN) and single family therapy (FT-AN). A total of 169 adolescents with a DSM-IV diagnosis of anorexia nervosa or eating disorder not otherwise specified (restricting type) were randomised to the two treatments using computer generated blocks of random sizes to ensure balanced numbers in the trial arms. Independent assessors, blind to the allocation, completed evaluations at baseline, 3 months, 12 months (end of treatment) and 18 months.ResultsBoth treatment groups showed clinically significant improvements with just under 60% achieving a good or intermediate outcome (on the Morgan-Russell scales) at the end of treatment in the FT-AN group and more than 75% in the MFT-AN group - a statistically significant benefit in favour of the multifamily intervention (OR = 2.55 95%; CI 1.17, 5.52; p = 0.019). At follow-up (18 months post baseline) there was relatively little change compared to end of treatment although the difference in primary outcome between the treatments was no longer statistically significant. Clinically significant gains in weight were accompanied by improvements in mood and eating disorder psychopathology. Approximately half the patients in FT-AN and nearly 60% of those in MFT-AN had started menstruating.ConclusionsThis study confirms previous research findings demonstrating the effectiveness of eating disorder focused family therapy and highlights the additional benefits of bringing together groups of families that maximises the use of family resources and mutual support leading to improved outcomes.Trial RegistrationCurrent Controlled Trials ISRCTN11275465; Registered 29 January 2007 (retrospectively registered)

【 授权许可】

CC BY   
© The Author(s). 2016