Candida glabrata endophthalmitis following penetrating keratoplasty in a patient with negative donor rim culture

BMC Ophthalmology

Case Report

Ismail Shatriah¹  Mohtar Ibrahim¹  Mohd Nor Muzaliha¹  Hussein Adil¹ 

[1] Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia;

关键词: Fluconazole;    Endophthalmitis;    Candida Glabrata;    Final Visual Acuity;    Bullous Keratopathy;   

DOI  :  10.1186/1471-2415-10-18

 received in 2010-02-10, accepted in 2010-06-11,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundCandida glabrata endophthalmitis following keratoplasty is rare and almost always associated with positive donor rim culture.Case presentationA 63-year-old patient, diagnosed Fuch's endothelial dystrophy in both eyes underwent a penetrating keratoplasty in his right eye. He had multiple underlying medical problems, which included diabetes mellitus, hypertension, hypoadrenalism on oral dexamethasone and fatty liver secondary to hypertrigliseridemia. He developed multiple suture abscesses, corneal haziness, retrocorneal white plaques and a level of hypopyon two weeks after an uneventful penetrating keratoplasty in his right eye. Cultures of the donor button and the transport media culture were negative. Candida glabrata was isolated successfully from the aqueous and vitreous taps. He was treated with a combination of topical, intracameral, intravitreal and intravenous Amphotericin B. His final visual acuity remained poor due to the haziness of the corneal button.ConclusionCandida glabrata endophthalmitis following penetrating keratoplasty can occur in negative donor rim and transport media cultures. The growth of the organism is facilitated by the patient's immunocompromised status. Awareness by the ophthalmologists and appropriate choice of antibiotics are mandatory in this challenging condition.

【 授权许可】

Unknown   
© Muzaliha et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.