The efficacy and safety of silodosin for the treatment of ureteral stones: a systematic review and meta-analysis

BMC Urology

Research Article

Jitao Wu¹  Yuanshan Cui¹  Diandong Yang¹  Hejia Yuan¹ 

[1] Department of Urology, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, NO.20 East Yuhuangding Road, 264000, Yantai, China;

关键词: Silodosin;    Ureteral stones;    Meta-analysis;    Randomized controlled trial;   

DOI  :  10.1186/s12894-016-0141-y

 received in 2015-05-09, accepted in 2016-05-17,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundTo evaluate the efficacy and safety of silodosin as a medical expulsive therapy for ureteral stones by means of a systematic review and meta-analysis.MethodsWe searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to identify randomized controlled trials (RCTs) of silodosin in the treatment of ureteral stones. The reference lists of retrieved studies were also investigated.ResultsSix RCTs, including 916 participants and comparing silodosin with controls, were used in the meta-analysis. Silodosin was superior to controls in terms of stone expulsion rate, the primary efficacy end point in all six RCTs (odds ratio [OR] for expulsion 2.16, 95 % confidence interval [CI] 1.62 to 2.86, p <0.00001). Silodosin was also more effective for secondary efficacy end points; the stone expulsion time (standardized mean difference [SMD] −3.66, 95 % CI −6.61 to −0.71; p =0.01) and analgesic requirements (SMD −0.89, 95 % CI −1.19 to −0.60; p < 0.00001) were significantly reduced compared with those of controls. Other than the incidence of abnormal ejaculation, which was higher in the silodosin groups (OR 2.84, 95 % CI 1.56 to 5.16, p =0.0006), few adverse effects were observed.ConclusionThis meta-analysis indicates silodosin is an effective and safe treatment option for ureteral stones with a low occurrence of side effects.

【 授权许可】

CC BY   
© Yang et al. 2016