Exhaled carbon monoxide: a non-invasive biomarker of short-term exposure to outdoor air pollution

BMC Public Health

Research Article

Jacqueline Wanjiku¹  N. Kingsley Ukwaja²  John R Balmes³  Parfait Houngbegnon⁴  Ambaliou Sanni⁵  Lucie Ayi Fanou⁵  Stephen B Gordon⁶  Benjamin Fayomi⁷  Vikkey Hinson⁷  Euripide Avokpaho⁷  Herve Lawin⁸ 

[1] Department of Internal Medicine, Egerton University, Njoro, Kenya;Department of Internal Medicine, Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria;Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA;Institut Regional de Santé Publique, University of Abomey Calavi, Cotonou, Benin;Laboratoire de Biochimie et de Biologie Moléculaire, FAST/UAC, Cotonou, Benin;Liverpool School of Tropical Medicine, Liverpool, UK;Unit of Teaching and Research in Occupational and Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin;Unit of Teaching and Research in Occupational and Environmental Health, Department of Public Health, Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin;Institut Regional de Santé Publique, University of Abomey Calavi, Cotonou, Benin;

关键词: Carbon monoxide;    Air pollution;    Biomarker;   

DOI  :  10.1186/s12889-017-4243-6

 received in 2016-09-23, accepted in 2017-04-06,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIn urban settings of Africa with rapidly increasing population, traffic-related air pollution is a major contributor to outdoor air pollution (OAP). Although OAP has been identified as a leading cause of global morbidity and mortality, there is however, lack of a simple biomarker to assess levels of exposure to OAP in resource-poor settings. This study evaluated the role of exhaled carbon monoxide (exhCO) as a potential biomarker of exposure to ambient carbon monoxide (ambCO) from OAP.MethodsThis was a descriptive study conducted among male commercial motorcycle riders in Cotonou – the economic capital of Benin. The participants’ AmbCO was measured using a portable carbon monoxide (CO) data logger for 8 h during the period of their shift. ExhCO was measured just before and immediately after their shift (8-h) Participants were asked not to cook or to smoke during the day of the measurements. Linear regression analysis was used to assess the association between ambCO and exhCO for the last 2, 4 and 6 h of their shift.ResultsOf 170 participants who completed the study, their mean ± SD age was 42.2 ± 8.4 years, and their mean ± SD daily income was 7.3 ± 2.7$. Also, 95% of the participants’ used solid fuels for cooking and only 2% had ever smoked. Average exhCO increased by 5.1 ppm at the end of the shift (p = 0.004). Post-shift exhCO was significantly associated to ambCO, this association was strongest for the last 2 h of OAP exposure before exhCO measurement (β = 0.34, p < 0.001).ConclusionExhCO level was associated with recent exposure to ambCO from OAP with measurable increase after 8 h of exposure. These findings suggest that ExhCO may be a potential biomarker of short-term exposure to OAP.

【 授权许可】

CC BY   
© The Author(s). 2017