Overnight orthokeratology is comparable with atropine in controlling myopia

BMC Ophthalmology

Research Article

Liuh-An Chen¹  Lei Wan²  Yu-Chuen Huang²  Fuu-Jen Tsai²  Hui-Ju Lin³  Alicia Lishin Tsai⁴  Yi-Yu Tsai⁴ 

[1] Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan;Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan;Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan;School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan;Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, 404, Taichung, Taiwan;School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan;Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan;Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan;

关键词: Atropine;    Axial length;    Cornea endothelium;    Myopia;    Orthokeratology;   

DOI  :  10.1186/1471-2415-14-40

 received in 2013-08-10, accepted in 2014-03-24,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMany efforts have been invested in slowing progression of myopia. Among the methods, atropine administration and orthokeratology (OK) are most widely used. This study analyzed the efficacy of atropine and OK lens in controlling myopia progression and elongation of axial length.MethodsThis retrospective study included 105 patients (210 eyes) who wore OK lenses and 105 patients (210 eyes) who applied 0.125% atropine every night during the 3 following period. Student t-test, linear regression analysis, repeated measure ANOVA, and Pearson’s correlation coefficient were used for statistical analysis.ResultsThe change in axial length per year was 0.28 ± 0.08 mm, 0.30 ± 0.09 mm, and 0.27 ± 0.10 mm in the OK lens group, and 0.38 ± 0.09 mm, 0.37 ± 0.12 mm, and 0.36 ± 0.08 mm in the atropine group for years 1, 2, and 3, respectively. Linear regression analysis revealed an increase in myopia of 0.28 D and 0.34 D per year, and an increase in axial length of 0.28 mm and 0.37 mm per year in the OK lens and atropine groups, respectively. Repeated measure ANOVA showed significant differences in myopia (p = 0.001) and axial length (p < 0.001) between the atropine and OK lens groups; in astigmatism, there was no significant difference in these parameters (p = 0.320). Comparison of increases in axial length in relation to baseline myopia showed significant correlations both in the OK lens group (Pearson’s correlation coefficient, r = 0.259; p < 0.001) and atropine group (r = 0.169; p = 0.014). High myopia patients benefited more from both OK lenses and atropine than did low myopia patients. The correlation of baseline myopia and myopia progression was stronger in the OK lens group then in the atropine group.ConclusionsOK lens is a useful method for controlling myopia progression even in high myopia patients.

【 授权许可】

Unknown   
© Lin et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.