A randomised controlled trial of mentalization-based treatment versus structured clinical management for patients with comorbid borderline personality disorder and antisocial personality disorder

BMC Psychiatry

Research Article

Jennifer O’Connell¹  Nicolas Lorenzini¹  Peter Fonagy¹  Tessa Gardner¹  Anthony Bateman² 

[1] The Anna Freud Centre, London, UK;Research Department of Clinical, Educational and Health Psychology, University College London, London, UK;University College London, London, UK;The Anna Freud Centre, London, UK;

关键词: Borderline personality disorder;    Antisocial personality disorder;    Randomised controlled trial;    Mentalization-based treatment;    Aggression;    Anger;    Treatment outcome;   

DOI  :  10.1186/s12888-016-1000-9

 received in 2016-04-15, accepted in 2016-08-12,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAntisocial personality disorder (ASPD) is an under-researched mental disorder. Systematic reviews and policy documents identify ASPD as a priority area for further treatment research because of the scarcity of available evidence to guide clinicians and policymakers; no intervention has been established as the treatment of choice for this disorder. Mentalization-based treatment (MBT) is a psychotherapeutic treatment which specifically targets the ability to recognise and understand the mental states of oneself and others, an ability shown to be compromised in people with ASPD. The aim of the study discussed in this paper is to investigate whether MBT can be an effective treatment for alleviating symptoms of ASPD.MethodsThis paper reports on a sub-sample of patients from a randomised controlled trial of individuals recruited for treatment of suicidality, self-harm, and borderline personality disorder. The study investigates whether outpatients with comorbid borderline personality disorder and ASPD receiving MBT were more likely to show improvements in symptoms related to aggression than those offered a structured protocol of similar intensity but excluding MBT components.ResultsThe study found benefits from MBT for ASPD-associated behaviours in patients with comorbid BPD and ASPD, including the reduction of anger, hostility, paranoia, and frequency of self-harm and suicide attempts, as well as the improvement of negative mood, general psychiatric symptoms, interpersonal problems, and social adjustment.ConclusionsMBT appears to be a potential treatment of consideration for ASPD in terms of relatively high level of acceptability and promising treatment effects.Trial registrationISRCTN ISRCTN27660668, Retrospectively registered 21 October 2008

【 授权许可】

CC BY   
© The Author(s). 2016