The impact of pretransplant 25-hydroxy vitamin D deficiency on subsequent graft function: An observational study

BMC Nephrology

Research Article

Hyunwook Kim¹  Kyu Hun Choi²  Shin-Wook Kang²  Tae-Hyun Yoo²  Myoung Soo Kim³  Yu Seun Kim³  Soon Il Kim³ 

[1] Department of Internal Medicine, Wonkwang University College of Medicine Sanbon Hospital, Gunpo-si, Kyunggi-do, South Korea;Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, 120-752, Seoul, South Korea;Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea;The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, South Korea;

关键词: Kidney Transplantation;    Graft Function;    Serum Albumin Level;    Acute Rejection Episode;    Early Graft Function;   

DOI  :  10.1186/1471-2369-13-22

 received in 2011-08-22, accepted in 2012-04-25,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundIn addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function. However, the effect of pretransplant serum vitamin D level on subsequent graft function has not been explored. Therefore, this study was undertaken to examine the effect of serum vitamin D level at the time of kidney transplantation (KT) on subsequent graft function.MethodsWe analyzed 106 patients who underwent KT and for whom 25-hydroxy vitamin D (25-OHD) levels were measured during hospitalization prior to transplantation. We measured estimated glomerular filtration rates (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula at baseline and at six-month intervals up to 36 months after KT.Results38.7% of the patients were diagnosed with 25-OHD deficiency defined as less than 10 ng/mL. Recipient gender (female vs. male, odds ratio [OR] 3.30, 95% CI 1.33-8.21, P = 0.010), serum albumin level (per 1 mg/dl increase, OR 0.35, 95% CI 0.13-0.98, P = 0.047), and predominant renal replacement therapy modality before KT (P < 0.001) were found to be independent pretransplant risk factors for 25-OHD deficiency by multivariate logistic regression analysis. Subsequent repeated measures analysis of covariance revealed that 25-OHD level had the only significant main effect on eGFR during the 36-month follow-up period [F (1, 88) = 12.07, P = 0.001].ConclusionsPretransplant 25-OHD deficiency was significantly associated with a lower post-transplant eGFR, suggesting that 25-OHD may play an important role in maintaining graft function after KT.

【 授权许可】

Unknown   
© Kim et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.