The effect of the medicine administration route on health-related quality of life: Results from a time trade-off survey in patients with bipolar disorder or schizophrenia in 2 Nordic countries

BMC Psychiatry

Research Article

Andreas Carlborg¹  Mette Bøgelund²  Karianne Dahlen³  Tine Rikke Jørgensen³  Charlotte Emborg⁴ 

[1] Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden;Incentive, Holte, Denmark;Medivir AB, Blasieholmsgatan 2, 111 48, Stockholm, Sweden;OPUS Klinikken, Risskov, Denmark;

关键词: Schizophrenia;    Bipolar Disorder;    Olanzapine;    Standard Gamble;    Loxapine;   

DOI  :  10.1186/s12888-016-0930-6

 received in 2015-10-27, accepted in 2016-06-09,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAgitation episodes are common among patients with schizophrenia or bipolar disorder. Oral and intramuscular administration methods are commonly used in pharmacological treatment of acute agitation. Recently, an innovative inhalation product with loxapine(Adasuve®)has become available for treatment of acute agitation episodes associated with bipolar disorder or schizophrenia. The objective for the present study was to investigate the impact of the pharmacological treatment’s administration methods on the health-related quality of life (HRQoL) in patients with bipolar disorder or schizophrenia in Denmark and Sweden using a time trade-off (TTO) approach.MethodsThe TTO methodology was used to examine the HRQoL impact of administration method of pharmacological treatment of acute agitation. Data were collected via an internet-based survey, using an existing panel of respondents with schizophrenia or bipolar disorder.ResultsRespondents considered living with schizophrenia/ bipolar disorder, having one yearly agitation episode treated with inhaler better than living with the same conditions and receiving treatment with tablet or injection. The utility value was 0.762 for inhalable treatment, 0.707 for injection and 0.734 for tablet treatment.ConclusionsPatients’ preference for treatment delivery options showed that inhalation was associated with a significant utility gain when compared to injection or tablets. Inhalable loxapine may be a new tool for control of agitation episodes for strengthening the patient provider alliance when taking patient’s preference for delivery method into consideration.

【 授权许可】

CC BY   
© The Author(s). 2016