Acupuncture with different acupoint combinations for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial

BMC Complementary and Alternative Medicine

Study Protocol

Tao Sha¹  Qiwen Zhang²  Lili Gao²  Bo Li²  Bo Chen²  Tianyi Zhao²  Jinxin Zou²  Yi Guo²  Xingfang Pan²  Yongming Guo² 

[1] College of Acupuncture and Massage, Tianjin University of Traditional Chinese Medicine, No. 312, Anshan West Road, Nankai District, 300193, Tianjin, China;College of Acupuncture and Massage, Tianjin University of Traditional Chinese Medicine, No. 312, Anshan West Road, Nankai District, 300193, Tianjin, China;Acupuncture Research Center, Tianjin University of Traditional Chinese Medicine, No. 312, Anshan West Road, Nankai District, 300193, Tianjin, China;

关键词: Acupuncture;    Chemotherapy-induced nausea and vomiting;    Acupoint combination;    Randomized controlled trial;   

DOI  :  10.1186/s12906-016-1425-1

 received in 2016-09-28, accepted in 2016-10-20,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundAcupuncture is beneficial for controlling chemotherapy-induced nausea and vomiting (CINV). However, the effect of different acupoint combinations on controlling CINV remains unknown. This study aims to compare the effects of distal-proximal point association and local distribution point association on controlling CINV.Methods/designThe study is a single-center, randomized controlled trial. A total of 240 participants will be randomly divided into four groups. The control group will receive standard antiemetic only, whereas three acupuncture groups will receive four electro-acupuncture treatments once a day with the standard antiemetic. Acupuncture group I and II will receive distal-proximal point association (“Neiguan (PC6) and Zhongwan (CV12)”, and “Zusanli (ST36) and CV12”, respectively); Acupuncture group III will receive local distribution point association (“Shangwan (CV13) and CV12”). The primary outcome measures are the frequency and distress of nausea and vomiting. The secondary outcome measures are the grade of constipation and diarrhea, electrogastrogram, quality of life, etc. Assessment is scheduled from the day before chemotherapy to the fifth day of chemotherapy. Follow-ups are performed from the sixth day to the twenty-first day of chemotherapy.DiscussionResults of this trial will help in evaluating the efficacy and safety of electro-acupuncture with different acupoint combinations in the management of CINV.Trial registrationClinicalTrials.gov identifier: NCT02478047.

【 授权许可】

CC BY   
© The Author(s). 2016