Association between markers of glycemia and carotid intima-media thickness: the MARK study

BMC Cardiovascular Disorders

Research Article

Natividad Garcia Regalado¹  Leticia Gomez-Sanchez²  Jose A. Maderuelo-Fernandez³  Jose I. Recio-Rodriguez³  Cristina Agudo-Conde³  Emiliano Rodriguez-Sanchez⁴  Manuel A. Gomez-Marcos⁴  Luis Garcia-Ortiz⁴  Maria C. Patino-Alonso⁵  Ruth Marti⁶  Rafel Ramos⁷ 

[1] CS San Agustín, Primare Care Ibsalut, Palma of Mallorca, Spain;Primary Care Research Unit, the Alamedilla Health Center, 37003, Salamanca, Spain;Primary Care Research Unit, the Alamedilla Health Center, 37003, Salamanca, Spain;Castilla and León Health Service–SACYL, REDIAPP. IBSAL, Salamanca, Spain;Primary Care Research Unit, the Alamedilla Health Center, 37003, Salamanca, Spain;Castilla and León Health Service–SACYL, REDIAPP. IBSAL, Salamanca, Spain;Medicine Department, University of Salamanca, Salamanca, Spain;Primary Care Research Unit, the Alamedilla Health Center, 37003, Salamanca, Spain;Statistics Department, University of Salamanca, Salamanca, Spain;Research Unit, Family Medicine, Girona, Spain;Jordi Gol Institute for Primary Care, Research (IDIAP Jordi Gol), Girona, Spain;Girona Biomedical Research Institute (IDIBGI), Dr. Trueta University Hospital, Catalonia, Spain;Research Unit, Family Medicine, Girona, Spain;Jordi Gol Institute for Primary Care, Research (IDIAP Jordi Gol), Girona, Spain;Translab Research Group. Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain;Girona Biomedical Research Institute (IDIBGI), Dr. Trueta University Hospital, Catalonia, Spain;

关键词: Intima-media thickness;    Fasting plasma glucose;    Postprandial glucose;    Glycosylated hemoglobin;   

DOI  :  10.1186/s12872-016-0380-6

 received in 2016-05-07, accepted in 2016-10-22,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundCarotid intima-media thickness (C-IMT) is a reliable predictor of cardiovascular events. We Investigated the relationship between markers of glycemia and C-IMT in intermediate-risk cardiovascular patients.MethodsThis study analyzed 427 subjects, aged 35 to 74 years (mean, 60.3 ± 8.5 years), 55 % women, enrolled into the MARK study. Including 231 subjects defined as normal glucose, 104 subjects classified as prediabetes and 92 with type 2 diabetes mellitus. Carotid ultrasound was used to measure C-IMT and the presence of plaques. Fasting plasma glucose (mg/dl) and glycated hemoglobin (%) (HbA1c) were measured using standard enzymatic automated methods. Postprandial glucose (mg/dl) was self-measured by patients at home 2 h after meals (breakfast, lunch and dinner) for 1 day.ResultsThe C-IMT shows a positive correlation with fasting plasma glucose, postprandial glucose and HbA1c. Multiple linear regression analysis showed a positive association between HbA1c and C-IMT, with a 0.016 mm and 0.019 mm increase in mean and maximum C-IMT per 1 % increase in HbA1c. In addition, an association between fasting plasma glucose and C-IMT was found with an increase of 0.004 and 0.005 mm in mean and maximum C-IMT per 10 mg/dl in fasting plasma glucose. We also observed a graded association between fasting plasma glucose, postprandial glucose and HbA1c and the presence of carotid target organ damage (TOD), with an odds ratio of 1.013, 1.010 and 1.425, respectively.ConclusionThe results of this study suggest that the fasting plasma glucose and HbA1c, but not postprandial glucose, are associated with C-IMT media and maximum. The patients who present with a metabolic glucose alteration have more risk of developing carotid TOD.Trial registrationClinicalTrials.gov; Identifier: NCT01428934.

【 授权许可】

CC BY   
© The Author(s). 2016