Cardiovascular disease prevalence in patients with inflammatory arthritis, diabetes mellitus and osteoarthritis: a cross-sectional study in primary care

BMC Musculoskeletal Disorders

Research Article

Mike JL Peters¹  Alper M van Sijl²  Michael T Nurmohamed³  Markus MJ Nielen⁴  Robert A Verheij⁴  François G Schellevis⁵ 

[1] Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands;Department of Rheumatology, Reade, Amsterdam, The Netherlands;Department of Rheumatology, Reade, Amsterdam, The Netherlands;Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands;NIVEL (Netherlands Institute for Health Services Research), P.O. Box 1568, 3500BN, Utrecht, The Netherlands;NIVEL (Netherlands Institute for Health Services Research), P.O. Box 1568, 3500BN, Utrecht, The Netherlands;Department of General Practice / EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands;

关键词: Osteoarthritis;    Inflammatory Arthritis;    Diabetes Mellitus Patient;    Multilevel Logistic Regression Analysis;    Increase Prevalence Rate;   

DOI  :  10.1186/1471-2474-13-150

 received in 2011-11-07, accepted in 2012-08-17,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThere is accumulating evidence for an increased cardiovascular burden in inflammatory arthritis, but the true magnitude of this cardiovascular burden is still debated. We sought to determine the prevalence rate of non-fatal cardiovascular disease (CVD) in inflammatory arthritis, diabetes mellitus and osteoarthritis (non-systemic inflammatory comparator) compared to controls, in primary care.MethodsData on CVD morbidity (ICPC codes K75 (myocardial infarction), K89 (transient ischemic attack), and/or K90 (stroke/cerebrovascular accident)) from patients with inflammatory arthritis (n = 1,518), diabetes mellitus (n = 11,959), osteoarthritis (n = 4,040) and controls (n = 158,439) were used from the Netherlands Information Network of General Practice (LINH), a large nationally representative primary care based cohort. Data were analyzed using multi-level logistic regression analyses and corrected for age, gender, hypercholesterolemia and hypertension.ResultsCVD prevalence rates were significantly higher in inflammatory arthritis, diabetes mellitus and osteoarthritis compared with controls. These results attenuated - especially in diabetes mellitus - but remained statistically significant after adjustment for age, gender, hypertension and hypercholesterolemia for inflammatory arthritis (OR = 1.5 (1.2-1.9)) and diabetes mellitus (OR = 1.3 (1.2-1.4)). The association between osteoarthritis and CVD reversed after adjustment (OR = 0.8 (0.7-1.0)).ConclusionsThese results confirm an increased prevalence rate of CVD in inflammatory arthritis to levels resembling diabetes mellitus. By contrast, lack of excess CVD in osteoarthritis further suggests that the systemic inflammatory load is critical to the CVD burden in inflammatory arthritis.

【 授权许可】

CC BY   
© Nielen et al.; licensee BioMed Central Ltd. 2012