Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors

BMC Cancer

Research Article

Steven Narod¹  Ming-Sound Tsao²  Frances A Shepherd²  Michael R Johnston²  Warren Rubenstein³  Darren R Brenner⁴  Rayjean J Hung⁴  John R McLaughlin⁵ 

[1] Dalla Lana School of Public Health, University of Toronto, 155 College St, M5T 3M7, Toronto, Ontario, Canada;Faculty of Medicine, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, Ontatrio, Canada;Women's College Health Research Institute, 790 Bay Street, M5G 1N8, Toronto, Ontario, Canada;Faculty of Medicine, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, Ontatrio, Canada;Princess Margaret Hospital, 610 University Ave, M5G 2M9, Toronto, Ontario, Canada;Mount Sinai Hospital Family Medicine Clinic, 60 Murray St, M5T 3L9, Toronto, Canada;Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, 60 Murray St, M5T 3L9, Toronto, Canada;Dalla Lana School of Public Health, University of Toronto, 155 College St, M5T 3M7, Toronto, Ontario, Canada;Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, 60 Murray St, M5T 3L9, Toronto, Canada;Dalla Lana School of Public Health, University of Toronto, 155 College St, M5T 3M7, Toronto, Ontario, Canada;Population Studies and Surveillance, Cancer Care Ontario, 620 University Ave, M5G 2L7, Toronto, Ontario, Canada;

关键词: Environmental Tobacco Smoke;    Lung Cancer Risk;    Environmental Tobacco Smoke Exposure;    Dust Exposure;    Great Toronto Area;   

DOI  :  10.1186/1471-2407-10-285

 received in 2009-11-26, accepted in 2010-06-14,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundWe conducted a case-control study in the greater Toronto area to evaluate potential lung cancer risk factors including environmental tobacco smoke (ETS) exposure, family history of cancer, indoor air pollution, workplace exposures and history of previous respiratory diseases with special consideration given to never smokers.Methods445 cases (35% of which were never smokers oversampled by design) between the ages of 20-84 were identified through four major tertiary care hospitals in metropolitan Toronto between 1997 and 2002 and were frequency matched on sex and ethnicity with 425 population controls and 523 hospital controls. Unconditional logistic regression models were used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the associations between exposures and lung cancer risk.ResultsAny previous exposure to occupational exposures (OR total population 1.6, 95% CI 1.4-2.1, OR never smokers 2.1, 95% CI 1.3-3.3), a previous diagnosis of emphysema in the total population (OR 4.8, 95% CI 2.0-11.1) or a first degree family member with a previous cancer diagnosis before age 50 among never smokers (OR 1.8, 95% CI 1.0-3.2) were associated with increased lung cancer risk.ConclusionsOccupational exposures and family history of cancer with young onset were important risk factors among never smokers.

【 授权许可】

Unknown   
© Brenner et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.