Statistical analysis of fractionation resistance by functional category and expression

BMC Genomics

Research

Eric C. H. Chen¹  Annie Morin²  David Sankoff³  Jean-Hugues Chauchat⁴ 

[1] Department of Biology, University of Ottawa, 30 Marie Curie, K1N 6N5, Ottawa, Canada;Department of Computer Science, Université de Rennes 1, 69676, Rennes Cedex, France;Department of Mathematics and Statistics, 585 King Edward, K1N 6N5, Ottawa, Canada;Laboratoire ERIC-Lyon2, Université de Lyon 2, 69676, Bron Cedex Cedex, France;

关键词: Gene loss;    Whole genome duplication;    Gene ontology;    Expression level;    Angiosperms;   

DOI  :  10.1186/s12864-017-3736-0

来源: Springer

【 摘 要 】

BackgroundThe current literature establishes the importance of gene functional category and expression in promoting or suppressing duplicate gene loss after whole genome doubling in plants, a process known as fractionation. Inspired by studies that have reported gene expression to be the dominating factor in preventing duplicate gene loss, we analyzed the relative effect of functional category and expression.MethodsWe use multivariate methods to study data sets on gene retention, function and expression in rosids and asterids to estimate effects and assess their interaction.ResultsOur results suggest that the effect on duplicate gene retention fractionation by functional category and expression are independent and have no statistical interaction.ConclusionIn plants, functional category is the more dominant factor in explaining duplicate gene loss.

【 授权许可】

CC BY   
© The Author(s) 2017