Fecal calprotectin level correlated with both endoscopic severity and disease extent in ulcerative colitis

BMC Gastroenterology

Research Article

Ryusaku Kusunoki¹  Naoki Oshima¹  Akihiko Oka¹  Kousaku Kawashima¹  Yasumasa Tada¹  Noritsugu Yamashita¹  Takafumi Yuki¹  Nobuhiko Fukuba¹  Hiroki Sonoyama¹  Yoshiyuki Mishima¹  Shunji Ishihara¹  Yoshikazu Kinoshita¹  Ichiro Moriyama²  Hideaki Kazumori³ 

[1] Department of Internal Medicine II, Shimane University Faculty of Medicine, 89-1, Enya-cho, 693-8501, Izumo, Shimane, Japan;Department of Internal Medicine II, Shimane University Faculty of Medicine, 89-1, Enya-cho, 693-8501, Izumo, Shimane, Japan;Cancer center, Shimane University Hospital, 89-1, Enya-cho, 693-8501, Izumo, Shimane, Japan;Division of Internal Medicine, Matsue Seikyo General Hospital, 8-8-8, Nishitsuda, 690-8522, Matsue, Japan;

关键词: Ulcerative colitis;    Fecal calprotectin;    Disease extent;   

DOI  :  10.1186/s12876-016-0462-z

 received in 2015-10-28, accepted in 2016-04-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and severity in UC patients.MethodsUC patients scheduled to undergo an ileocolonoscopy were enrolled and fecal samples for FC measurement were collected prior to the procedure. A Mayo endoscopic subscore (MES) was determined for each of 5 colonic segments. To evaluate the association of FC with extent of affected mucosa as well as disease severity, we assessed the correlation of FC level with the sum of MES (S-MES) for the 5 colonic segments as compared to the maximum score of MES (M-MES).ResultsFC measurements in conjunction with findings from 136 complete colonoscopies in 102 UC patients were evaluated. FC level showed a stronger correlation with S-MES (correlation coefficient r = 0.86, p < 0.001) as compared to M-MES (r = 0.79, p < 0.001). In patients with an M-MES of 1, 2, and 3, FC level showed a significant correlation with S-MES (r = 0.67, p < 0.001; r = 0.70, p < 0.001; r = 0.47, p = 0.04, respectively). Our findings indicate that FC level is elevated in patients with greater areas of affected mucosa even in those with the same M-MES value.ConclusionsFC level was shown to be correlated with the extent of affected mucosa as well as severity in UC patients, thus it is useful for precise assessment of mucosal inflammation.

【 授权许可】

CC BY   
© Kawashima et al. 2016