Efficacy and tolerability of preservative-free 0.0015% tafluprost in glaucoma patients: a prospective crossover study

BMC Ophthalmology

Research Article

Wonseok Lee¹  HyoungWon Bae²  Sunghoon Lee²  Gong Je Seong²  Chan Yun Kim² 

[1] Department of Ophthalmology, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea;Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, #211Eonjuro, Gangnam-gu, 06273, Seoul, Republic of Korea;

关键词: Tafluprost;    Preservative;    Efficacy;    Tolerability;   

DOI  :  10.1186/s12886-017-0453-z

 received in 2016-05-26, accepted in 2017-04-22,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe aim of this work is to evaluate efficacy and tolerability of preservative containing 0.0015% tafluprost and preservative-free 0.0015% tafluprost using a prospective crossover study.MethodsPrimary open angle glaucoma (POAG) and normotensive glaucoma (NTG) patients were randomized enrolled. Group 1 (“NPT to PT”) patients used preservative-free 0.0015% tafluprost (NPT) for 6 months and then changed to preservative containing 0.0015% tafluprost(PT) for 6 months. Group 2 (“PT to NPT”) patients used preservative containing 0.0015% tafluprost for 6 months and changed to preservative-free 0.0015% tafluprost for 6 months. At 1, 3, 6, 7, 9, and 12 months, we measured intraocular pressure for efficacy and graded corneal erosion, tear break-up time (TBUT), and subjective discomfort.ResultsA total of 20 patients and 20 eyes were enrolled. In Group 1 and 2, intraocular pressure was well controlled to approximately 14 mmHg (9.38–18.46% decrease). Generally, subjective satisfaction was improved after changing from PT to NPT (p = 0.03) and TBUT using PT was numerically inferior to that using NPT (p = 0.06) but not when changing from NPT to PT.ConclusionBoth preservative containing and preservative-free 0.0015% tafluprost reduced intraocular pressure significantly. In addition, changing medication from PT to NPT might improve subjective satisfaction and tear break up time.Trial registrationThe trial registration number is NCT 03104621 (Apr/1/2017). Retrospectively registered.

【 授权许可】

CC BY   
© The Author(s). 2017