Renal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial

BMC Nephrology

Research Article

Cláudio G Lima¹  Rodrigo A Oliveira¹  Elizabeth F Daher²  Geraldo B Silva Junior³  Rosa Ms Mota⁴  Talita R Sanches⁵  Antônio C Seguro⁶  Lúcia C Andrade⁶  Alexandre B Libório⁷  Alice Mc Martins⁸ 

[1] Department of Internal Medicine, School of Medicine, Federal University of Ceará, Campus Cariri, Rua Divino Salvador, 284, CEP-63180-000, Centro, Barbalha, Ceará, Brazil;Department of Internal Medicine, School of Medicine, Federal University of Ceará, Campus Fortaleza, Fortaleza, Ceará, Brazil;Brazilian National Research Council (CNPq), São Paulo, Brazil;Department of Internal Medicine, School of Medicine, Federal University of Ceará, Campus Fortaleza, Fortaleza, Ceará, Brazil;School of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil;Department of Statistics, Sciences Center, Federal University of Ceará, Fortaleza, Ceará, Brazil;Division of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil;Division of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil;Brazilian National Research Council (CNPq), São Paulo, Brazil;School of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Ceará, Brazil;School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil;

关键词: American cutaneous leishmaniasis;    Renal function;    Tubular defects;    Treatment;   

DOI  :  10.1186/1471-2369-13-44

 received in 2011-11-24, accepted in 2012-06-14,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundRenal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction.MethodsA prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial.ResultsThe patients mean age was 35.6 ± 12 years and 19 were male. Before treatment, urinary concentrating defect (U/Posm <2.8) was identified in 27 patients (77%) and urinary acidification defect in 17 patients (46%). No significant glomerular dysfunction was observed before and after specific ACL treatment. There was no reversion of urinary concentrating defects, being observed in 77% of the patients before and in 88% after treatment (p = 0.344). Urinary acidification defect was corrected in 9 patients after treatment, reducing its prevalence from 40% before to only 16% after treament, (p = 0.012). Microalbuminuria higher than 30 mg/g was found in 35% of patients before treatment and in only 8% after treatment. Regarding fractional excretion of sodium, potassium, calcium, phosphorus and magnesium, there was no significant difference between pre and post-treatment period.ConclusionAs previously described, urinary concentrating and acidification defects were found in an important number of patients with ACL. Present results demonstrate that only some patients recover urinary acidification capacity, while no one returned to normal urinary concentration capacity.

【 授权许可】

CC BY   
© Oliveira et al.; licensee BioMed Central Ltd. 2012