Cotinine versus questionnaire: early-life environmental tobacco smoke exposure and incident asthma

BMC Pediatrics

Research Article

Moira Chan-Yeung¹  Anne DyBuncio¹  Chris Carlsten¹  Helen Dimich-Ward¹  Allan B Becker² 

[1] Department of Medicine, University of British Columbia, Vancouver, BC, Canada;Department of Pediatrics, University of Manitoba, Winnipeg, MB, Canada;

关键词: Children;    Exposure to environmental tobacco smoke;    Bronchial hyperresponsiveness;    Wheeze;    Asthma;   

DOI  :  10.1186/1471-2431-12-187

 received in 2012-06-01, accepted in 2012-11-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe use of biomarkers has expanded considerably, as an alternative to questionnaire-based metrics of environmental tobacco smoke (ETS); few studies have assessed the affect of such alternative metrics on diverse respiratory outcomes in children, and we aimed to do so.MethodsWe evaluated various measures of birth-year ETS, in association with multiple respiratory endpoints early years of life, in the novel context of a birth cohort at high risk for asthma. We administered questionnaires to parents, both at the end of pregnancy and at one year of life, and measured cotinine in cord blood (CCot; in 275 children) and in urine (UCot; obtained at 12 months in 365 children), each by radioimmunoassay. Multiple logistic regression was used to assess the association of the various metrics with recurrent wheeze at age 2 and with bronchial hyperresponsiveness (BHR) and asthma at age 7.ResultsSelf-reported 3rd trimester maternal smoking was associated with significantly increased risk for recurrent wheeze at age 2 (odds ratio 3.5 [95% confidence interval = 1.2,10.7]); the risks associated with CCot and 3rd trimester smoking in any family member were similar (OR 2.9 [1.2,7.0] and 2.6 [1.0,6.5], respectively). No metric of maternal smoking at 12 months appeared to significantly influence the risk of recurrent wheeze at age 2, and no metric of ETS at any time appeared to significantly influence risk of asthma or BHR at age 7.ConclusionsBiomarker- and questionnaire-based assessment of ETS in early life lead to similar estimates of ETS-associated risk of recurrent wheeze and asthma.

【 授权许可】

CC BY   
© Carlsten et al.; licensee BioMed Central Ltd. 2012