期刊论文详细信息
BMC Psychiatry
Melancholic versus non-melancholic depression: differences on cognitive function. A longitudinal study protocol
Study Protocol
Joan Salvà1  Mauro García-Toro1  Joan Llobera2  Rosa Molina3  Margalida Gili4  Natalia Bauza4  Margalida Vives4  Saray Monzón4  Miquel Roca4  Maria Jesus Serrano4 
[1] Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of Balearic Islands (UIB), Ctra, Valldemossa km 7., 07122, Palma de Mallorca, Balearic Islands, Spain;Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of Balearic Islands (UIB), Ctra, Valldemossa km 7., 07122, Palma de Mallorca, Balearic Islands, Spain;Direcció General d'Avaluació i Acreditació, Conselleria Salut i Consum, Govern de les Illes Balears, C/de Carles I, 6, 07003, Palma de Mallorca, Balearic Islands, Spain;Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of Balearic Islands (UIB), Ctra, Valldemossa km 7., 07122, Palma de Mallorca, Balearic Islands, Spain;Servei de Psiquiatria, Hospital de Manacor, Ctra, Manacor-Alcudia s/n, 07500, Manacor, Balearic Islands, Spain;Institut Universitari d'Investigacions en Ciències de la Salut (IUNICS), University of Balearic Islands (UIB), Ctra, Valldemossa km 7., 07122, Palma de Mallorca, Balearic Islands, Spain;Unitat de Psiquiatria i Psicologia Clinica, Hospital Joan March, University of Balearic Islands, Ctra, Sóller s/n, 07110, Bunyola, Balearic Islands, Spain;
关键词: Major Depressive Disorder;    Depressed Patient;    Major Depressive Disorder;    Clinical Remission;    Hamilton Depression Rate Scale;   
DOI  :  10.1186/1471-244X-10-48
 received in 2010-05-20, accepted in 2010-06-17,  发布年份 2010
来源: Springer
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【 摘 要 】

BackgroundCognitive dysfunction is common among depressed patients. However, the pattern and magnitude of impairment during episodes of major depressive disorder (MDD) through to clinical remission remains unclear. Heterogeneity of depressive patients and the lack of longitudinal studies may account for contradictory results in previous research.Methods/DesignThis longitudinal study will analyze cognitive differences between CORE-defined melancholic depressed patients (n = 60) and non-melancholic depressed patients (n = 60). A comprehensive clinical and cognitive assessment will be performed at admission and after 6 months. Cognitive dysfunction in both groups will be longitudinally compared, and the persistence of cognitive impairment after clinical remission will be determined.DiscussionThe study of neuropsychological dysfunction and the cognitive changes through the different phases of depression arise a wide variety of difficulties. Several confounding variables must be controlled to determine if the presence of depression could be considered the only factor accounting for group differences.

【 授权许可】

CC BY   
© Monzón et al; licensee BioMed Central Ltd. 2010

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