Expression of matrix metalloproteinases 1, 3, and 9 in degenerated long head biceps tendon in the presence of rotator cuff tears: an immunohistological study

BMC Musculoskeletal Disorders

Research Article

Stefan Lakemeier¹  Christian D Peterlein¹  Susanne Fuchs-Winkelmann¹  Christian Foelsch¹  Eleni Archontidou-Aprin¹  Markus D Schofer¹  Juergen RJ Paletta¹  Soeren A Schwuchow¹ 

[1] Department of Orthopedics and Rheumatology, University Hospital Marburg, Marburg, Germany;

关键词: Rotator Cuff;    Rotator Cuff Tear;    Full Thickness Tear;    Rotator Cuff Disease;    Partial Thickness Tear;   

DOI  :  10.1186/1471-2474-11-271

 received in 2010-06-28, accepted in 2010-11-25,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundLong head biceps (LHB) degeneration, in combination with rotator cuff tears, can be a source of chronic shoulder pain. LHB tenotomy reduces pain and improves joint function although the pathophysiological context is not well understood. Tendon integrity depends on the extracellular matrix (ECM), which is regulated by matrix metalloproteinases (MMP). It is unclear which of these enzymes contribute to LHB but we chose to study MMP 1, 3, and 9 and hypothesized that one or more of them may be altered in LHB, whether diagnosed preoperatively or intraoperatively. We compared expression of these MMPs in both LHB and healthy tendon samples.MethodsLHB samples of 116 patients with degenerative rotator cuff tears were harvested during arthroscopic tenotomy. Patients were assigned to 4 groups (partial thickness tear, full thickness tear, cuff arthropathy, or control) based upon intraoperative findings. Partial and full thickness tears were graded according to Ellman and Bateman's classifications, respectively. MMP expression was determined by immunohistochemistry.ResultsMMP 1 and 9 expression was significantly higher in the presence of rotator cuff tears than in controls whereas MMP 3 expression was significantly decreased. MMP 1 and 9 expression was significantly higher in articular-sided than bursal-sided partial thickness tears. No significant association was found between MMP 1 and 9 expression and full thickness tears, and the extent of the cuff tear by Bateman's classification.ConclusionIncreased MMP 1 and 9 expression, and decreased MMP 3 expression are found in LHB degeneration. There is a significant association between the size and location of a rotator cuff tear and MMP expression.

【 授权许可】

CC BY   
© Lakemeier et al; licensee BioMed Central Ltd. 2010