Rapid predictors for the occurrence of reduced left ventricular ejection fraction between LAD and non-LAD related ST-elevation myocardial infarction

BMC Cardiovascular Disorders

Research Article

Ju-Ying Qian¹  Xian-Hong Shu¹  Zhang-Wei Chen¹  Zi-Qing Yu¹  Hong-Bo Yang¹  Jun-Bo Ge¹  Ying-Hua Chen² 

[1] Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032, Shanghai, PR China;Department of Endocrinology Medicine, East Hospital, Tongji University School of Medicine, 200120, Shanghai, China;

关键词: ST-elevation myocardial infarction;    Left ventricular ejection fraction;    Primary percutaneous coronary intervention;    Predictors;   

DOI  :  10.1186/s12872-015-0178-y

 received in 2015-10-14, accepted in 2015-12-18,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundsReduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), which implies the occurrence of cardiac dysfunction, impacts cardiac prognosis, even after primary percutaneous coronary intervention (PCI). This study was designed to clarify the difference of clinical and angiographic predictors for reduced LVEF in ST-elevation myocardial infarction (STEMI) patients with left anterior descending artery (LAD) or non-LAD vessel as culprit artery.MethodsThis was a retrospective study to review a total of 553 patients of STEMI underwent primary PCI in our hospital. All patients underwent echocardiography. Univariate analysis, multivariate analysis and classification and regression tree (CART) were performed between LAD related AMI and non-LAD related STEMI. The primary outcome was the occurrence of reduced LVEF 4–6 days after PCI.ResultsIn this study, culprit arteries of STEMI were 315 in LAD system (6 in left main artery, 309 in LAD) and 238 in non-LAD system (63 in left circumflex and 175 in right coronary artery). Compared with non-LAD group, post-MI LVEF was significantly reduced in LAD related STEMI group (52.4 ± 9.3 % vs. 57.1 ± 7.8 %, P < 0.01). Multivariate analysis indicated that elder (>65 years), time to hospital and proximal occlusion were associated with reduced LVEF (<55 %) in LAD related STEMI patients. However, in non-LAD patients, time to hospital, multivessel stenosis and post-PCI blood pressure predicted the occurrence of reduced LVEF. Furthermore, CART analysis also obtained similar findings.ConclusionsPatients with LAD or non-LAD related STEMI could suffer reduced LVEF, while the clinical and angiographic predictors for the occurrence were different.

【 授权许可】

CC BY   
© Chen et al. 2016