Clinicopathological features and prognostic validity of WHO grading classification of SI-NENs

BMC Cancer

Research Article

Cheng Fang¹  Wei Wang¹  Huishan Chen²  Ye Chen²  Tianming Xu³  Jingnan Li³  Meng Zhang⁴  Lin Zhou⁴  Luohai Chen⁵  Minhu Chen⁵  Jie Chen⁵  Rong Lin⁶  Panpan Zhang⁷  Lin Shen⁷  Jie Li⁷  Liang Shang⁸  Leping Li⁸  Huangying Tan⁹  Pan Zhang⁹  Meng Qiu^1,10  Kaizhou Jin^1,11  Xianjun Yu^1,11  Qin Zhang^1,12 

[1] Department of Gastric Surgery, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China;Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China;Department of Gastroenterology, Peking Union Medical College Hospital, Beijing, China;Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan II Road, Yuexiu District, 510080, Guangzhou, China;Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China;Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research under Ministry of Education, Peking University Cancer Hospital & Beijing Cancer Hospital, No.52 Fucheng Road, Haidian District, 100142, Beijing, China;Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No.324 Jingwu Road, Huaiyin District, 250021, Jinan, China;Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing, China;Department of Medical Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, China;Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China;Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: Neuroendocrine neoplasms;    Small intestine;    Clinicopathological characteristics;    Tumor grade;   

DOI  :  10.1186/s12885-017-3490-3

 received in 2017-03-29, accepted in 2017-07-18,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe clinicopathological characteristics of small intestinal neuroendocrine neoplasms (SI-NENs) and the prognostic validity of WHO grading classification for SI-NENs are still unknown in Asian patients.Methods277 patients and 8315 patients with SI-NENs were retrieved respectively from eleven Chinese hospitals and Surveillance, Epidemiology, and End Results (SEER) cancer registry. Overall survival was used as the major study outcome. Survival analysis using Kaplan-Meier analysis with log-rank test and cox regression analysis were applied.ResultsClinicopathological characteristics of SI-NENs were quite different among different races. Duodenum was the predominant tumor site in Chinese patients and Asian/Pacific Islander patients but not in white patients from SEER database. Patients with duodenal NENs tended to have more localized disease than patients with jejunal/ileal NENs which were confirmed by patients from SEER database. Grade 3 or poorly differentiated/undifferentiated tumor were more common and tumor size was significantly larger in ampullary NENs compared with that in non-ampullary duodenal NENs. As for the prognostic validity of WHO grading classification, survival between patients with grade 1 and grade 2 disease was not significantly different. Ki-67 index of 5% might be a better threshold between grade 1 and grade 2 than Ki-67 index of 2% in SI-NENs.ConclusionsOur study revealed that the clinicopathological characteristics of SI-NENs among different races were quite different. This might because duodenal NENs was much more common in Chinese patients and Asian/Pacific Islander patients. Duodenal NENs and jejunal/ileal NENs, ampullary and non-ampullary duodenal NENs shared different characteristics. Ki-67 index of 5% might be a better threshold between grade 1 and grade 2 in SI-NENs.

【 授权许可】

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© The Author(s). 2017