Prognostic impact of CD168 expression in gastric cancer

BMC Cancer

Research Article

Shinichi Ueno¹  Hiroshi Kurahara¹  Hideo Arima¹  Kita Yoshiaki¹  Yasuto Uchikado¹  Masataka Matsumoto¹  Tetsuro Setoyama¹  Masaki Kitazono¹  Shoji Natsugoe¹  Yuko Kijima¹  Sumiya Ishigami¹  Yuka Nishizono¹  Takaaki Arigami¹ 

[1] Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan;

关键词: Gastric Cancer;    Hyaluronic Acid;    CD168 Expression;    Gastric Cancer Cell;    Gastric Cancer Patient;   

DOI  :  10.1186/1471-2407-11-106

 received in 2010-06-02, accepted in 2011-03-24,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundInteractions of stromal hyaluronic acid (HA) with its binding protein RHAMM (receptor for HA-mediated motility) (CD168) have been reported to affect tumor extension and the migration of crucial molecules to promote tumor progression and metastases. Cancerous CD168 expression is correlated with aggressive biological features in several cancers. However, the clinical implications of CD168 positivity in gastric cancer have remained unclear.MethodsWe examined the CD168 expression of 196 consecutive gastric cancer patients by immunohistochemistry. According to CD168 positivity, the 196 gastric cancer patients were divided into two groups (57 CD168-positive and 139 CD168-negative patients). The correlation between CD168 expression and clinicopathological factors (age, sex, histology, tumor depth, lymph node status, and vessel invasion) was evaluated according to the Japanese Classification of Gastric Carcinoma.ResultsCancerous CD168 expression was detectable in 57 of the 196 tumors (29%). CD168 positivity was significantly correlated with the depth of invasion, nodal involvement, and vessel invasion (p < 0.01). Survival analysis of the 196 gastric cancer patients showed that the CD168-positive group had a significantly higher mortality than the CD168-negative group (p < 0.01). In terms of a correlation with CD168 positivity at separate clinical stages, a significance difference was only found in stages II and III. Multivariate analysis revealed that CD168 expression was a significant independent prognostic marker (p = 0.013) after depth of invasion (p < 0.005) and nodal involvement (p < 0.01).ConclusionOur results suggest that cancerous CD168 positivity is strongly related to the invasion and metastasis of gastric cancer tumors. These results suggest that cancerous CD168 expression can be used as a prognostic marker of gastric cancer owing to its interactions with stromal hyaluronic acid.

【 授权许可】

CC BY   
© Ishigami et al; licensee BioMed Central Ltd. 2011