BMC Psychiatry | |
COMPULS: design of a multicenter phenotypic, cognitive, genetic, and magnetic resonance imaging study in children with compulsive syndromes | |
Study Protocol | |
Tobias Banaschewski1  Daniel Brandeis2  Jilly Naaijen3  Jeffrey C. Glennon3  Marcel P. Zwiers3  Jan K. Buitelaar4  David J. Lythgoe5  Steven C. R. Williams5  Barbara Franke6  Saskia de Ruiter7  Sarah Durston8  | |
[1] Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany;Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty, Mannheim/Heidelberg University, Mannheim, Germany;Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland;Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland;Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland;Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, Nijmegen, EZ, The Netherlands;Department of Cognitive Neuroscience, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Geert Grooteplein Noord 10 (Huispost 126), 6525, Nijmegen, EZ, The Netherlands;Karakter child and adolescent psychiatry university center, Nijmegen, The Netherlands;Department of Neuroimaging, King’s College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK;Departments of Human Genetics and Psychiatry, Donders Institute of Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands;Karakter child and adolescent psychiatry university center, Nijmegen, The Netherlands;NICHE lab, department of psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands; | |
关键词: Compulsivity; Fronto-striatal circuit; Glutamate; ADHD; ASD; OCD; | |
DOI : 10.1186/s12888-016-1072-6 | |
received in 2016-05-03, accepted in 2016-10-14, 发布年份 2016 | |
来源: Springer | |
【 摘 要 】
BackgroundCompulsivity, the closely linked trait impulsivity and addictive behaviour are associated with several neurodevelopmental disorders, including attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive compulsive disorder (OCD). All three disorders show impaired fronto-striatal functioning, which may be related to altered glutamatergic signalling. Genetic factors are also thought to play an important role in the aetiology of compulsivity-related disorders.MethodsThe COMPULS study is a multi-center study designed to investigate the relationship between the traits compulsivity, impulsivity, and, to a lesser extent, addictive behaviour within and across the neurodevelopmental disorders ADHD, ASD, and OCD. This will be done at the phenotypic, cognitive, neural, and genetic level. In total, 240 participants will take part in COMPULS across four different sites in Europe. Data collection will include diagnostic interviews, behavioural questionnaires, cognitive measures, structural, functional and spectral neuroimaging, and genome-wide genetic information.DiscussionThe COMPULS study will offer the unique opportunity to investigate several key aspects of compulsivity across a large cohort of ADHD, ASD and OCD patients.
【 授权许可】
CC BY
© The Author(s). 2016
【 预 览 】
Files | Size | Format | View |
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RO202311091410240ZK.pdf | 761KB | download |
【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]
- [43]
- [44]
- [45]
- [46]
- [47]
- [48]
- [49]
- [50]
- [51]
- [52]
- [53]
- [54]
- [55]
- [56]
- [57]
- [58]
- [59]
- [60]
- [61]
- [62]
- [63]
- [64]