PAI-1 and t-PA/PAI-1 complex potential markers of fibrinolytic bleeding after cardiac surgery employing cardiopulmonary bypass

BMC Anesthesiology

Research Article

Lars J Bjertnaes¹  Inta Jaunalksne²  Agnese Ozolina³  Eva Strike⁴  Indulis Vanags⁵  Angelika Krumina⁶ 

[1] Anaesthesia and Critical Care Research Group, Department of Clinical Medicine (Anaesthesiology), Faculty of Medicine, University of Tromsø, MH-Breivika, 9038, Tromsø, Norway;Department of Anaesthesiology, University Hospital of North Norway, Sykehusveien 38, 9038, Tromsø, Norway;Clinical Immunology Centre, Pauls Stradins Clinical University Hospital, Pilsonu street 13, Riga, Latvia;Department of Anaesthesiology and Cardiac surgery, Pauls Stradins Clinical University Hospital, Pilsonu street 13, Riga, Latvia;Department of Anaesthesiology and Cardiac surgery, Pauls Stradins Clinical University Hospital, Pilsonu street 13, Riga, Latvia;Department of Anaesthesiology and Reanimatology, Riga Stradins University, Dzirciema street 16, Riga, Latvia;Department of Anaesthesiology and Reanimatology, Riga Stradins University, Dzirciema street 16, Riga, Latvia;Department of Infectology and Dermatology, Riga Stradins University, Dzirciema street 16, Riga, Latvia;

关键词: Cardiac surgery;    Fibrinolysis;    Plasminogen activator inhibitor;    Tissue plasminogen activator;   

DOI  :  10.1186/1471-2253-12-27

 received in 2012-02-21, accepted in 2012-10-23,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundEnhanced bleeding remains a serious problem after cardiac surgery, and fibrinolysis is often involved. We speculate that lower plasma concentrations of plasminogen activator inhibitor – 1 (PAI-1) preoperatively and tissue plasminogen activator/PAI-1 (t-PA/PAI-1) complex postoperatively might predispose for enhanced fibrinolysis and increased postoperative bleeding.MethodsTotally 88 adult patients (mean age 66 ± 10 years) scheduled for cardiac surgery, were enrolled into a prospective study. Blood samples were collected pre-operatively, on admission to the recovery and at 6 and 24 hours postoperatively. Patients with a surgical bleeding that was diagnosed during reoperation were discarded from the study. The patients were allocated to two groups depending on the 24-hour postoperative chest tube drainage (CTD): Group I > 500ml, Group II ≤ 500ml. Associations between CTD, PAI-1, t-PA/PAI-1 complex and D-dimer were analyzed with SPSS.ResultsNine patients were excluded because of surgical bleeding. Of the 79 remaining patients, 38 were allocated to Group I and 41 to Group II. The CTD volumes correlated with the preoperative plasma levels of PAI-1 (r = − 0.3, P = 0.009). Plasma concentrations of preoperative PAI-1 and postoperative t-PA/PAI-1 complex differed significantly between the groups (P < 0.001 and P = 0.012, respectively). Group I displayed significantly lower plasma concentrations of fibrinogen and higher levels of D-dimer from immediately after the operation and throughout the first 24 hours postoperatively.ConclusionsLower plasma concentrations of PAI-1 preoperatively and t-PA/PAI-1 complex postoperatively leads to higher plasma levels of D-dimer in association with more postoperative bleeding after cardiac surgery.

【 授权许可】

CC BY   
© Ozolina et al.; licensee BioMed Central Ltd. 2012