High prevalence of coexisting prehypertension and prediabetes among healthy adults in northern and northeastern China

BMC Public Health

Research Article

Hai-tao Ding¹  Xu-zhen Qin²  Xin-qi Chen²  Xiu-zhi Guo²  Liang-yu Xia²  Wei Wu²  Jie Wu²  Ling Qiu²  Yan-hong Liu³  Wen-hua Yan⁴  Cheng-li Xu⁵  Shao-mei Han⁵  Guang-jin Zhu⁵ 

[1] Department of Clinical Laboratory, Inner Mongolian People's Hospital, 010017, Hohhot, China;Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, 100730, Beijing, China;Department of Clinical Laboratory, The 2nd Affiliated Hospital of Harbin Medical University, 150001, Harbin, China;Department of Endocrinology, Chinese PLA General Hospital, 100853, Beijing, China;Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 100005, Beijing, China;

关键词: Fasting Blood Glucose;    Impaired Fasting Glucose;    Postprandial Blood Glucose;    Serum Glucose Concentration;    Mongolian Autonomous Region;   

DOI  :  10.1186/1471-2458-11-794

 received in 2011-08-12, accepted in 2011-10-12,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundPrehypertension and prediabetes are major risk factors of cardiovascular disease, and their combined presence may result in more serious cardiovascular outcomes than expected with either prehypertension or prediabetes alone. The aim of the present study was to evaluate the prevalence of coexisting prehypertension and prediabetes, and the associated risk profiles in a Chinese population.MethodsA cross-sectional survey in a representative sample of 3,595 men and 4,593 women aged 18 years and older was performed between 2008 and 2010. Prehypertension and prediabetes were diagnosed using the guidelines from the Seventh Report of the Joint National Committee on prevention, detection, and treatment of high blood pressure and American Diabetes Association, respectively. Prehypertension was defined as a systolic blood pressure of 120-139 mmHg and/or diastolic blood pressure of 80-89 mmHg, and prediabetes was defined as a fasting blood glucose of 5.6-6.9 mmol/L.ResultsThe prevalence of coexisting prehypertension and prediabetes was 11.0%. Men had a higher prevalence of coexisting prehypertension and prediabetes than women (14.2% vs. 8.4%; P < 0.0001). This prevalence increased with age and body mass index, and was the lowest among Mongolian-Chinese (5.1%). A multivariate analysis showed that γ-glutamyltransferase and uric acid were significantly and positively correlated with body mass index, waist circumference, blood pressure, triglycerides, and total cholesterol, and negatively correlated with high density lipoprotein cholesterol in subjects with prehypertension and prediabetes.ConclusionsThere is a large proportion of Chinese adults with coexisting prehypertension and prediabetes. Thus, there is a need for more efforts that implement public health programs that target the earlier stages of hypertension and diabetes.

【 授权许可】

Unknown   
© Wu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.