Measuring transcutaneous bilirubin: a comparative analysis of three devices on a multiracial population

BMC Pediatrics

Research Article

Silvia Lama¹  Angela Carla Borrelli¹  Rosalba Maffucci¹  Maria Sellitto¹  Letizia Capasso¹  Francesco Raimondi¹  Paola Milite¹  Francesca Landolfo¹ 

[1] Division of Neonatology, Department of Pediatrics, Università “Federico II”, Via Pansini 5, 80131, Napoli, Italy;

关键词: Receiver Operating Curve;    Total Serum Bilirubin;    Wide Concentration Range;    Neonatal Jaundice;    Neonatal Hyperbilirubinemia;   

DOI  :  10.1186/1471-2431-12-70

 received in 2011-05-07, accepted in 2012-03-01,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundHyperbilirubinemia can lead to potentially irreversible bilirubin-induced neurotoxicity. Transcutaneous bilirubin (TcB) determination has become a valuable aid in non invasive screening of neonatal jaundice.The aim of this study is to compare the performance of three most widespread transcutaneous bilirubinometers on a multiracial population of term and late pre-term neonates.MethodsBilirubin concentration was determined using traditional photometric determination and transcutaneously with Bilicheck, BiliMed and JM-103, in random order.Total serum bilirubin (TSB) was determined over a wide concentration range (15,8–0,7 mg/dl) with a mean of 9,5 mg/dl. Related TcB values using Bilicheck (TcB-BC), BiliMed (TcB-BM), and JM-103 (TcB-JM) are reported in Table 1.ResultsA multiracial population of 289 neonates was enrolled with a gestational age ranging from 35 to 41 weeks; birth weight ranging from 1800to 4350 grams; hours of life ranging from 4 to 424. In the total study population correlation analysis using Pearson coefficients showed good results for Bilicheck (r = 0.86) and JM-103 (r = 0.85) but poor for BiliMed (r = 0,70). Similar results were found for the non-Caucasian neonates subgroup. Bilicheck and JM-103 had a greater area under the curve than BiliMed when TSB =14 mg/dl was chosen as a threshold value both for the total study population and the non-Caucasian subgroup.ConclusionsBilicheck and JM-103, but not BiliMed, are equally reliable screening tools for hyperbilirubinemia in our multiracial neonatal population.

【 授权许可】

CC BY   
© Raimondi et al.; licensee BioMed Central Ltd. 2012