A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China

BMC Infectious Diseases

Research Article

Jinglan Shan¹  Changan Li¹  Dan Ye¹  Pu Mao²  Weiqun He³  Yongbo Huang³  Jianchun Li³  Yimin Li³  Xiaoqing Liu³ 

[1] Department of Infection Control, The First Affiliated Hospital of Guangzhou medical university, 510120, Guangzhou, Guangdong, China;State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou medical university, 510120, Guangzhou, Guangdong, China;State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou medical university, 510120, Guangzhou, Guangdong, China;Intensive Care Unit, The First Affiliated Hospital of Guangzhou medical university, 510120, Guangzhou, Guangdong, China;

关键词: Outbreak;    Acinetobacter baumannii;    ICU;    Gloves;   

DOI  :  10.1186/s12879-015-0917-9

 received in 2015-01-12, accepted in 2015-03-31,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundImipenem-resistant Acinetobacter baumannii (IRAB) is an important cause of hospital-acquired infection. We aimed to describe an outbreak of IRAB infection and to investigate its possible source in an intensive care unit.MethodsAn environmental investigation was undertaken. Antimicrobial susceptibility testing was performed by microdilution. These isolates were genotyped by use of repetitive extragenic palindromic polymerase chain reaction (rep-PCR; DiversiLab). The study included 11 patients infected with IRAB and 14 control patients free of IRAB. Case and control patients were compared for possible predisposing factors. A multifaceted intervention was implemented to control the outbreak.ResultsThirty-nine IRABs were isolated from patients and the environmental surveillance culture in August, November, and December 2011. All isolates were resistant to imipenem. The IRAB strains belonged to seven clones (A–G) by the use of rep-PCR. There were four epidemic clones (D–G) in the outbreak, and Clone D was predominant. For the case–control study, patients with chronic obstructive pulmonary disease were susceptible to infection with IRAB. The hospital mortality of the case group was significantly higher than that of the control group.ConclusionsThe outbreak strains were transmitted among infected patients and equipment by inappropriate use of gloves. A combination of aggressive infection control measures is essential for preventing recurrent nosocomial outbreaks of IRAB.

【 授权许可】

Unknown   
© Dan et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.