Viral etiology of community-acquired pneumonia among adolescents and adults with mild or moderate severity and its relation to age and severity

BMC Infectious Diseases

Research Article

Li Gu¹  Yi-Min Wang¹  Xiao-Min Yu¹  Ying-Mei Liu¹  Ran Li¹  Jiu-Xin Qu¹  Bin Cao¹  Zeng-Hui Pu²  Chen Wang³ 

[1] Department of Infectious diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing Institute of Respiratory Medicine, No 8 Gongti Nanlu, ChaoYang District, 100020, Beijing, China;Department of Infectious diseases, YanTai Yu Huang-Ding Hospital, Yantai, China;Department of Respiratory Medicine, Capital Medical University; Beijing Institute of Respiratory Medicine; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, China;

关键词: Community-acquired pneumonia;    Respiratory viral infection;    Pneumonia severity index;    Adolescent;    Adult;    Influenza virus A;    Adenovirus;    Human rhinovirus;   

DOI  :  10.1186/s12879-015-0808-0

 received in 2014-02-26, accepted in 2015-02-06,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundBetter knowledge of distribution of respiratory viruses (RVs) in adolescents and adults with community-acquired pneumonia (CAP) is needed.MethodsTo investigate the RVs etiology among adolescents and adults with CAP, according to age and pneumonia severity index (PSI), a multi-center, prospective study was conducted from November 2010 to April 2012. Fifteen RVs were tested by polymerase chain reaction (PCR). Bacteria were detected by urinary antigen, conventional culture and PCR.ResultsMean (SD) age and median (IQR) PSI score of 954 patients enrolled was 45.2 (19.5) years (range 14–94) and 42 (36). RVs were found in 262 patients (27.5%): influenza virus A (IFV A, 9.9%) comprised of pandemic H1N1 (6.7%) and seasonal H3N2 (3.5%), human rhinovirus (4.3%), adenovirus (4.2%), human metapneumovirus (1.8%), parainfluenza virus 1, 3 and 2 (1.7%, 1.5% and 1.2%). Influenza virus B, enterovirus, respiratory syncytial virus, human coronavirus and parainfluenza virus 4 were rarely detected (<1%). Frequency of IFV A was highest among patients aged between 45–64 years (p < 0.001), while adenovirus among patients aged 14–17 years (p < 0.001), no differences was found in other RVs. The proportion of pandemic H1N1 increased with severity of pneumonia evaluated by PSI (P < 0.05).ConclusionsThe proportion of RVs in CAP is higher than previously reported. IFV A pneumonia are usually found in patients older than 45 years, while, adenovirus pneumonia are common in adolescents and young adults. Pandemic H1N1 virus is still recognized by PSI as a high-severity pathogen. The findings contribute baseline data on viral CAP study in China.

【 授权许可】

Unknown   
© Qu et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.