Peripheral artery disease and exertional leg symptoms in diabetes patients in Ghana

BMC Cardiovascular Disorders

Research Article

Joana Ainuson¹  Peter Puplampu²  Josephine Akpalu²  Albert G. B. Amoah³  Kwame Yeboah⁴  Ben Gyan⁵ 

[1] Department of Dietetics, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana;Department of Medicine & Therapeutics, School of Medicine & Dentistry, University of Ghana, Accra, Ghana;Department of Medicine & Therapeutics, School of Medicine & Dentistry, University of Ghana, Accra, Ghana;National Diabetes Management & Research Centre, Korle-Bu Teaching Hospital, Accra, Ghana;Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, P. O. Box KB 143, Accra, Ghana;Noguchi Memorial Institute of Medical Research, University of Ghana, Accra, Ghana;

关键词: Diabetes;    Peripheral arterial disease;    Ankle brachial index;    Exertional leg symptoms;    Ghana;   

DOI  :  10.1186/s12872-016-0247-x

 received in 2015-08-04, accepted in 2016-04-14,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPeripheral arterial disease (PAD) is a major health problem in diabetes patients in high-income countries, but the PAD burden in sub-Saharan Africa is largely undetermined. We studied the prevalence of PAD and exertional leg symptoms in diabetes (DM) patients in a tertiary hospital in Ghana.MethodsIn a case control study design, 485 DM and 330 non-diabetes participants were recruited. PAD was diagnosed as Ankle Brachial Index (ABI) < 0.9. Edinburgh Claudication Questionnaire (ECQ) was used to assess exertional leg symptoms.ResultsThe overall prevalence of classical intermittent claudication was 10.3 % and ABI-diagnosed PAD was 26.7 %, with 3.5 % of the participants having both classic intermittent claudication and ABI-diagnosed PAD. The prevalence of exertional leg symptoms were similar in diabetes patients with and without PAD. In non-diabetes participants, intermittent claudication and rest pain were higher in PAD patients than in non-PAD participants. In multivariable logistic regression, intermittent claudication [OR (95 % CI), 3.39 (1.14 – 8.1), p < 0.05] and rest pain [4.3 (1.58 – 9.67), p < 0.001] were independently associated with PAD in non-diabetes group, and rest pain [1.71 (1.13 – 2.17), p < 0.05] was associated with PAD in all participants.ConclusionsThere is high burden of PAD and exertional leg pains in DM patients in Ghana. PAD is expressed as intermittent claudication and rest pain in non-diabetes individuals.

【 授权许可】

CC BY   
© Yeboah et al. 2016