A partially supervised physical activity program for adult and adolescent survivors of childhood cancer (SURfit): study design of a randomized controlled trial [NCT02730767]

BMC Cancer

Study Protocol

Helge Hebestreit¹  Nicolas X. von der Weid²  Christina Schindera³  Christian Meier⁴  Simeon J. Zuercher⁵  Susi Kriemler⁵  Corina S. Rueegg⁶  Andrea Renner⁷  Prisca Eser⁸ 

[1]Children’s Hospital, University Hospital Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

[2]Department of Pediatric Oncology and Hematology, University Children’s Hospital Basel (UKBB), University of Basel, Spitalstrasse 33, 4056, Basel, Switzerland

[3]Department of Pediatric Oncology and Hematology, University Children’s Hospital Basel (UKBB), University of Basel, Spitalstrasse 33, 4056, Basel, Switzerland

[4]Institute of Social and Preventive Medicine, University of Bern, Finkenhubelweg 11, 3012, Bern, Switzerland

[5]Division of Endocrinology, Diabetes, Metabolism and Bone Research, University Hospital Basel, Missionsstrasse 24, 4055, Basel, Switzerland

[6]Epidemiology, Biostatistics and Prevention Institute, University of Zürich, Hirschengraben 84, 8001, Zürich, Switzerland

[7]Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital and Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372, Oslo, Norway

[8]Department of Health Sciences and Health Policy, University of Lucerne, Frohburgstrasse 3, 6002, Lucerne, Switzerland

[9]Paediatric Endocrinology, Pediatric Endocrinology Centre Zurich AG (PEZZ), Möhrlistrasse 69, 8006, Zürich, Switzerland

[10]University Clinic of Cardiology, Preventive Cardiology and Sports Medicine, Inselspital, University Hospital Bern, 3010, Bern, Switzerland

关键词: Randomized controlled trial;    Physical activity;    Exercise intervention;    Childhood cancer survivors;    Late-effects;    Cardiovascular disease;    Bone health;    Body composition;    Physical fitness;    Quality of life;   

DOI  :  10.1186/s12885-017-3801-8

 received in 2017-08-09, accepted in 2017-11-20,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundBeyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today’s survivors suffer from short- and long-term adverse effects such as cardiovascular and pulmonary diseases, obesity, osteoporosis, fatigue, depression, and reduced physical fitness and quality of life. Regular exercise can play a major role to mitigate or prevent such late-effects. Despite this, there are no data on the effects of regular exercise in childhood cancer survivors from randomized controlled trials (RCTs). Primary outcome of the current RCT is therefore the effect of a 12-months exercise program on a composite cardiovascular disease risk score in childhood cancer survivors. Secondary outcomes are single cardiovascular disease risk factors, glycaemic control, bone health, body composition, physical fitness, physical activity, quality of life, mental health, fatigue and adverse events (safety).MethodsA total of 150 childhood cancer survivors aged ≥16 years and diagnosed ≥5 years prior to the study are recruited from Swiss paediatric oncology clinics. Following the baseline assessments patients are randomized 1:1 into an intervention and control group. Thereafter, they are seen at month 3, 6 and 12 for follow-up assessments. The intervention group is asked to add ≥2.5 h of intense physical activity/week, including 30 min of strength building and 2 h of aerobic exercises. In addition, they are told to reduce screen time by 25%. Regular consulting by physiotherapists, individual web-based activity diaries, and pedometer devices are used as motivational tools for the intervention group. The control group is asked to keep their physical activity levels constant.DiscussionThe results of this study will show whether a partially supervised exercise intervention can improve cardiovascular disease risk factors, bone health, body composition, physical activity and fitness, fatigue, mental health and quality of life in childhood cancer survivors. If the program will be effective, all relevant information of the SURfit physical activity intervention will be made available to interested clinics that treat and follow-up childhood cancer patients to promote exercise in their patients.Trial registrationProspectively registered in clinicaltrials.gov [NCT02730767], registration date: 10.12.2015.

【 授权许可】

CC BY   
© The Author(s). 2017