Serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients: a case-control study

BMC Cancer

Research Article

Vaclav Eis¹  Jan Hrbacek²  Jiri Heracek³  Michael Urban³  Marek Brabec⁴  Eva Hamsikova⁵  Ruth Tachezy⁵ 

[1] 3rd Faculty of Medicine, Department of Pathology, Charles University in Prague, Prague, Czech Republic;3rd Faculty of Medicine, Department of Urology, Charles University in Prague, Prague, Czech Republic;3rd Faculty of Medicine, Department of Urology, Charles University in Prague, Prague, Czech Republic;Androgeos, Prague, Czech Republic;Department of Nonlinear Modelling, Institute of Computer Science, Academy of Sciences of the Czech Republic, Prague, Czech Republic;Institute of Hematology and Blood Transfusion, Prague, Czech Republic;

关键词: Herpes Simplex Virus;    Benign Prostate Hyperplasia;    Gleason Score;    Chlamydia Trachomatis;    Seropositivity Rate;   

DOI  :  10.1186/1471-2407-11-53

 received in 2010-10-19, accepted in 2011-02-03,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundInfection plays a role in the pathogenesis of many human malignancies. Whether prostate cancer (PCa) - an important health issue in the aging male population in the Western world - belongs to these conditions has been a matter of research since the 1970 s. Persistent serum antibodies are a proof of present or past infection. The aim of this study was to compare serum antibodies against genitourinary infectious agents between PCa patients and controls with benign prostate hyperplasia (BPH). We hypothesized that elevated serum antibody levels or higher seroprevalence in PCa patients would suggest an association of genitourinary infection in patient history and elevated PCa risk.MethodsA total of 434 males who had undergone open prostate surgery in a single institution were included in the study: 329 PCa patients and 105 controls with BPH. The subjects' serum samples were analysed by means of enzyme-linked immunosorbent assay, complement fixation test and indirect immunofluorescence for the presence of antibodies against common genitourinary infectious agents: human papillomavirus (HPV) 6, 11, 16, 18, 31 and 33, herpes simplex virus (HSV) 1 and 2, human cytomegalovirus (CMV), Chlamydia trachomatis, Mycoplasma hominis, Ureaplasma urealyticum, Neisseria gonorrhoeae and Treponema pallidum. Antibody seroprevalence and mean serum antibody levels were compared between cases and controls. Tumour grade and stage were correlated with serological findings.ResultsPCa patients were more likely to harbour antibodies against Ureaplasma urealyticum (odds ratio (OR) 2.06; 95% confidence interval (CI) 1.08-4.28). Men with BPH were more often seropositive for HPV 18 and Chlamydia trachomatis (OR 0.23; 95% CI 0.09-0.61 and OR 0.45; 95% CI 0.21-0.99, respectively) and had higher mean serum CMV antibody levels than PCa patients (p = 0.0004). Among PCa patients, antibodies against HPV 6 were associated with a higher Gleason score (p = 0.0305).ConclusionsAntibody seropositivity against the analyzed pathogens with the exception of Ureaplasma does not seem to be a risk factor for PCa pathogenesis. The presence or higher levels of serum antibodies against the genitourinary pathogens studied were not consistently associated with PCa. Serostatus was not a predictor of disease stage in the studied population.

【 授权许可】

Unknown   
© Hrbacek et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.