期刊论文详细信息
BMC Medical Genetics
Association of CACNG6 polymorphisms with aspirin-intolerance asthmatics in a Korean population
Research Article
Inseon S Choi1  Byung-Lae Park2  Hyun Sub Cheong2  Joon Seol Bae3  Tae Joon Park3  Charisse Flerida Pasaje3  Jin Sol Lee3  Jeong-Hyun Kim3  Jason Yongha Kim3  Hyoung Doo Shin4  Choon-Sik Park5  Soo-Taek Uh5  Mi-Kyeong Kim6  An-Soo Jang7  Jong-Sook Park7 
[1] Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences, 501-757, Gwangju, South Korea;Department of Genetic Epidemiology, SNP Genetics, Inc., 153-801, Seoul, South Korea;Department of Life Science, Sogang University, 121-742, Seoul, South Korea;Department of Life Science, Sogang University, 121-742, Seoul, South Korea;Department of Genetic Epidemiology, SNP Genetics, Inc., 153-801, Seoul, South Korea;Division of Allergy and Respiratory Medicine, Soonchunhyang University Seoul Hospital, 140-743, Seoul, South Korea;Division of Internal Medicine, Chungbuk National University, College of Medicine, 361-711, Cheongju, South Korea;Genome Research Center for Allergy and Respiratory Disease, Soonchunhyang University Bucheon Hospital, 420-767, Bucheon, South Korea;
关键词: Chronic Obstructive Pulmonary Disease;    Airway Smooth Muscle;    Korean Population;    Nasal Polyposis;    Azelastine;   
DOI  :  10.1186/1471-2350-11-138
 received in 2010-06-22, accepted in 2010-09-23,  发布年份 2010
来源: Springer
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【 摘 要 】

BackgroundAspirin-intolerant asthma (AIA) occurs in the lower and upper airways through excessive production of leukotrienes upon administration of non-steroidal anti-inflammatory drugs (NSAIDs). One of the three symptoms of AIA is nasal polyposis, a chronic inflammatory disease that is related to the function of calcium ion in recruitment of immune cells during airway inflammation. It has been implicated that bronchodilation in the airway is related to Ca(2+) regulation. The calcium channel, voltage-dependent, gamma subunit 6 (CACNG6) gene encodes a protein that stabilizes the calcium channel.MethodsTo study the associations between AIA and polymorphisms in CACNG6 gene, eight variants were genotyped in 102 AIA cases and 429 aspirin-tolerant asthma (ATA) controls. Logistic analyses were used to evaluate the associations of CACNG6 polymorphisms with AIA.ResultsStatistical analyses revealed that a single nucleotide polymorphism (SNP; rs192808C > T; P = 0.0004, Pcorr = 0.0029, OR = 2.88 in co-dominant model; P = 0.0005, Pcorr = 0.0036, OR = 2.99 in dominant model) in intron and a haplotype unique to this variant (CACNG6_BL1_ht6; P = 0.003, Pcorr = 0.02, OR = 2.57 in co-dominant model, P = 0.001, Pcorr = 0.0087, OR = 2.81 in dominant model) were significantly associated with the risk of AIA.ConclusionsOur results suggest that the CACNG6 variants might be associated with the risk of AIA in a Korean population.

【 授权许可】

Unknown   
© Lee et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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