Clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater

BMC Gastroenterology

Research Article

Do Youn Park¹  Nari Shin²  Suk Kim³  Sung Pil Yun⁴  Hyung Il Seo⁴  Kwangho Yang⁵ 

[1] Department of Pathology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, 602-739, Busan, South Korea;Department of Pathology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, 50612, Yangsan, Gyeongsangnam-do, South Korea;Department of Radiology, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, 602-739, Busan, South Korea;Department of Surgery, Biomedical Research Institute, Pusan National University Hospital, 179, Gudeok-Ro, Seo-Gu, 602-739, Busan, South Korea;Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, 50612, Yangsan, Gyeongsangnam-do, South Korea;Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulgeum-eup, 50612, Yangsan, Gyeongsangnam-do, South Korea;

关键词: Neoplasms;    Neuroendocrine tumors;    Ampulla of Vater;    Pancreaticoduodenectomy;    Treatment outcome;   

DOI  :  10.1186/s12876-017-0630-9

 received in 2016-11-16, accepted in 2017-05-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe study aims to investigate the clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater (NETAoVs) patients who underwent pancreaticoduodenectomy.MethodsFrom January 2007 to December 2014, 45 patients underwent pancreaticoduodenectomy for malignant disease of the ampulla of Vater in our institution. Of those, 5 patients were diagnosed as neuroendocrine tumors. The data included age, sex, presenting symptoms, preoperative imaging, preoperative type of biopsy results, type of operation, pathologic findings and survival status.ResultsThe patient’s mean age was 55.2 ± 9.7 years. Endoscopic ultrasound guided biopsy was performed in 4 patients and gastroduodenoscopic biopsy was performed in one patient. All showed neuroendocrine tumor without mitosis. Mean tumor size was 1.9 ± 0.56 cm (range, 1.2–2.0 cm). Lymph node metastases were detected in two patients. All patients were synaptophysin-positive. Median periods of follow-up were 45 months (range, 43–78 months). Recurrence after operation occurred in two patients. 4 patients were alive at the last follow-up.ConclusionsRadical resection for NETAoVs can provide the information of status of lymph node metastasis after surgery. However, correlation between lymph node metastasis and overall survival is uncertain to date.

【 授权许可】

CC BY   
© The Author(s). 2017