期刊论文详细信息
BMC Complementary and Alternative Medicine | |
Electro-acupuncture on functional peripheral nerve regeneration in mice: a behavioural study | |
Research Article | |
Frédérique Scamps1  Chamroeun Sar1  Ngoc Son Hoang2  Victor Sieso3  Jean Valmier4  | |
[1]Inserm, U 1051, F-34000, Montpellier, France | |
[2]Inserm, U 1051, F-34000, Montpellier, France | |
[3]Hanoi Medical University, Hanoi, Vietnam | |
[4]Inserm, U 1051, F-34000, Montpellier, France | |
[5]University Montpellier I, F-34000, Montpellier, France | |
[6]Inserm, U 1051, F-34000, Montpellier, France | |
[7]University Montpellier II, F-34000, Montpellier, France | |
关键词: Sciatic nerve; Crush; Nerve injury; Pain; Sensorimotor; | |
DOI : 10.1186/1472-6882-12-141 | |
received in 2012-03-28, accepted in 2012-07-08, 发布年份 2012 | |
来源: Springer | |
【 摘 要 】
BackgroundThe improvement of axonal regeneration is a major objective in the treatment of peripheral nerve injuries. The aim of this study was to evaluate the effects of electro-acupuncture on the functional recovery of sensorimotor responses following left sciatic nerve crush in mice.MethodsSciatic nerve crush was performed on seven week old female mice. Following the injury, the control group was untreated while the experimental group received an electro-acupuncture application to the injured limb under isoflurane anesthesia at acupoints GB 30 and GB 34. Mechanical and heat sensitivity tests were performed to evaluate sensory recovery. Gait analysis was performed to assess sensorimotor recovery.ResultsOur results show that normal sensory recovery is achieved within five to six weeks with a two-week period of pain preceding the recovery to normal sensitivity levels. While electro-acupuncture did not accelerate sensory recovery, it did alleviate pain-related behaviour but only when applied during this period. Application before the development of painful symptoms did not prevent their occurrence. The analysis of gait in relation to the sensory tests suggests that the electro-acupuncture specifically improved motor recovery.ConclusionsThis study demonstrates that electro-acupuncture exerts a positive influence on motor recovery and is efficient in the treatment of pain symptoms that develop during target re-innervation.【 授权许可】
Unknown
© Hoang et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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