Analyzing the field of bioinformatics with the multi-faceted topic modeling technique

BMC Bioinformatics

Research

Jeong-Hoon Lee¹  Go Eun Heo²  Min Song²  Keun Young Kang² 

[1] Department of Creative IT Engineering, POSTECH, 77 Cheongam-ro Nam-gu, 37673, Pohang, Gyeongbuk, Republic of Korea;Department of Library and Information Science, Yonsei University, 50 Yonsei-ro Seodaemun-gu, 03722, Seoul, Republic of Korea;

关键词: Bioinformatics;    Text mining;    Topic modeling;    ACT model;    Keyphrase extraction;   

DOI  :  10.1186/s12859-017-1640-x

来源: Springer

【 摘 要 】

BackgroundBioinformatics is an interdisciplinary field at the intersection of molecular biology and computing technology. To characterize the field as convergent domain, researchers have used bibliometrics, augmented with text-mining techniques for content analysis. In previous studies, Latent Dirichlet Allocation (LDA) was the most representative topic modeling technique for identifying topic structure of subject areas. However, as opposed to revealing the topic structure in relation to metadata such as authors, publication date, and journals, LDA only displays the simple topic structure.MethodsIn this paper, we adopt the Tang et al.’s Author-Conference-Topic (ACT) model to study the field of bioinformatics from the perspective of keyphrases, authors, and journals. The ACT model is capable of incorporating the paper, author, and conference into the topic distribution simultaneously. To obtain more meaningful results, we use journals and keyphrases instead of conferences and bag-of-words.. For analysis, we use PubMed to collected forty-six bioinformatics journals from the MEDLINE database. We conducted time series topic analysis over four periods from 1996 to 2015 to further examine the interdisciplinary nature of bioinformatics.ResultsWe analyze the ACT Model results in each period. Additionally, for further integrated analysis, we conduct a time series analysis among the top-ranked keyphrases, journals, and authors according to their frequency. We also examine the patterns in the top journals by simultaneously identifying the topical probability in each period, as well as the top authors and keyphrases. The results indicate that in recent years diversified topics have become more prevalent and convergent topics have become more clearly represented.ConclusionThe results of our analysis implies that overtime the field of bioinformatics becomes more interdisciplinary where there is a steady increase in peripheral fields such as conceptual, mathematical, and system biology. These results are confirmed by integrated analysis of topic distribution as well as top ranked keyphrases, authors, and journals.

【 授权许可】

CC BY   
© The Author(s). 2017