Adherence to and appropriateness of anti-osteoporotic treatments in patients aged 50 and over in the Valencia Region (Spain). The ESOSVAL-AD Study

BMC Musculoskeletal Disorders

Study Protocol

Isabel Hurtado¹  Gabriel Sanfélix-Gimeno¹  Salvador Peiró¹  Inmaculada Ferreros¹  José Sanfélix-Genovés²  Vicente Giner Ruiz³  José Luis Trillo⁴  Ruth Usó⁴  Manuel Pascual de la Torre⁵ 

[1] Centro Superior de Investigación en Salud Pública (Center for Public Health Research), Valencia, Spain;Centro Superior de Investigación en Salud Pública (Center for Public Health Research), Valencia, Spain;Centro de Salud de Nazaret, Departamento València-Clínic-Malvarrosa, Agencia Valenciana de Salud, Valencia, Spain;Centro de Salud Ciudad Jardín, Departamento de Alacant-Hospital General, Agencia Valenciana de la Salud, Alicante, Spain;Dirección General de Farmacia y Productos Sanitarios, Agencia Valenciana de Salud, Valencia, Spain;Oficina de Abucasis, Agencia Valenciana de Salud, Valencia, Spain;

关键词: Vertebral Fracture;    Fracture Risk;    Osteoporotic Fracture;    Zoledronic Acid;    Electronic Medical Record System;   

DOI  :  10.1186/1471-2474-12-178

 received in 2011-07-25, accepted in 2011-08-03,  发布年份 2011

来源: Springer

【 摘 要 】

ackgroundA study to evaluate the adherence to and appropriateness of anti-osteoporotic treatments in a cohort of men and women aged 50 and over participating in the ESOSVAL-R study.Methods/DesignDesign: An observational, longitudinal, prospective cohort study; Study subjects: Men and women aged 50 and over living in the Valencia Region (Spain) who initiated treatment between June 15, 2009, and June 15, 2011, in primary healthcare centers with electronic medical records; Data sources: The main data source will be electronic medical records. Measurement of results: Degree of compliance with and persistence of anti-osteoporotic treatments, and the proportion of patients with appropriate anti-osteoporotic treatment in accordance with the most relevant and high impact recommendations with clearly defined treatment algorithms in Spain (the Spanish National Health System guide (2010), the General Practitioners' Society (2007) and the General Directorate for Pharmacy and Medical Products of Madrid (2007)), and with the National Osteoporosis Foundation (NOF, 2010), and the International Osteoporosis Foundation guidelines (IOF, 2008); Analysis: 1.) Descriptive analysis of patients undergoing treatment and the treatments prescribed; 2.) Descriptive analysis of compliance with and persistence of anti-osteoporotic treatments; 3.) Analysis of factors associated with compliance with and persistence of treatments by Cox proportional hazard regression models, 4.) Descriptive analysis of appropriateness of treatment; 5.) Analysis of factors associated with the appropriateness of treatment by multilevel models (4 levels: patient, doctor, Basic Healthcare Zone/Primary Healthcare Center, and Health Area variables).DiscussionESOSVAL-AD will provide information regarding adherence to osteoporosis treatments and the factors associated with a higher or lower adherence (including the appropriateness of the treatment) in the Spanish context. A better understanding of this phenomenon and the interventions needed to address it would contribute to the increased effectiveness of therapeutic measures, a reduction in morbidity and mortality, and a corresponding reduction in healthcare costs.

【 授权许可】

CC BY   
© Sanfélix-Gimeno et al; licensee BioMed Central Ltd. 2011