Effects of immunonutrition on biomarkers in traumatic brain injury patients in Malaysia: a prospective randomized controlled trial

BMC Anesthesiology

Research Article

Mohamad Irfan Othman Jailani¹  Mustafa Kassim Abdulazez Kassim¹  Gracie Ong¹  Pui San Loh¹  Jeyaganesh S. Veerakumaran¹  Lee Fern Phang²  Pei Chien Tah³  Rafidah Othman³  Amirah Amir⁴  Sheau Fung Sia⁵  Vineya Rai Hakumat Rai⁶ 

[1]Department of Anaesthesiology, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia

[2]Department of Anaesthesiology, Hospital Umum Sarawak, Jalan Hospital, 93586, Kuching, Sarawak, Malaysia

[3]Department of Dietetics, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia

[4]Department of Parasitology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

[5]Division of Neurosurgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

[6]School of Medicine, Taylor’s University, Lakeside Campus, 47500, Subang Jaya, Malaysia

[7]KPJ Tawakkal Specialist Hospital, Jalan Pahang Barat, 53000, Kuala Lumpur, Malaysia

关键词: Biomarkers;    Immunonutrition;    Traumatic brain injury;    Neomune;    Enteral nutrition;    Cytokines;   

DOI  :  10.1186/s12871-017-0369-4

 received in 2016-11-17, accepted in 2017-05-31,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundHead injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients.MethodsThirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015. Patients were randomized to receive either an immunonutrition (Group A) or a standard (Group B) enteral feed. Levels of biomarkers were measured at day 1, 5 and 7 of enteral feeding.ResultsPatients in Group A showed significant reduction of IL-6 at day 5 (p < 0.001) with concurrent rise in glutathione levels (p = 0.049). Patients in Group A also demonstrated a significant increase of total protein level at the end of the study (day 7).ConclusionThese findings indicate the potential of immunonutrition reducing cytokines and increasing antioxidant indices in patients with TBI. However, further studies incorporating patient outcomes are needed to determine its overall clinical benefits.Trial registrationNational Medical Research Register (NMRR) ID: 14–1430-23,171. ClinicalTrials.gov identifier: NCT03166449.

【 授权许可】

CC BY   
© The Author(s). 2017