A cross-sectional analysis of the relationship between uric acid and coronary atherosclerosis in patients with suspected coronary artery disease in China

BMC Cardiovascular Disorders

Research Article

Yujiao Sun¹  Xin Yu¹  Ling Chen¹  Chunwei Wu¹  Song Geng¹  Ying Zhi¹  Hua Li¹  Guoxian Qi¹  Ting Liu²  Ke Xu² 

[1] Department of Cardiology of Aging, Department of Cardiology, The First Affiliated Hospital of China Medical University, NO.155 Nanjing North Street, Heping Ward, 110001, Shenyang, China;Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China;

关键词: Uric acid;    Coronary atherosclerosis;    Coronary computed tomography angiography;    Gender;    Calcium score;   

DOI  :  10.1186/1471-2261-14-101

 received in 2013-08-12, accepted in 2014-07-31,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundAlthough many studies have examined the relationship between uric acid (UA) and coronary artery disease (CAD), whether UA is an independent risk factor contributing to progression of CAD is still controversial. Whether UA plays a different role in different sexes is also unclear.MethodsA total of 1116 individuals with suspected CAD were stratified into four groups according to their serum UA quartiles in total (men and women combined), in men, and in women. The association of UA with coronary atherosclerosis was assessed by univariable and multivariable logistic regression.ResultsIn total and in women, the prevalence of any plaques and significant/severe stenosis was significantly increased with an increase in quartiles of UA (all P < 0.05). The proportion of triple-vessel disease and left main artery lesion was highest in the fourth quartile (both p < 0.05). Increasing quartiles of UA were significantly associated with a coronary artery calcium score (CACS) >10 (all P < 0.01). As UA levels increased in women, the incidence of double-vessel lesions (p = 0.017) and the proportion of mixed plaques (p = 0.022) were significantly increased. The proportion of a CACS of 0 in total, in men and women was highest in the first quartile (all P < 0.01). UA was the strongest predictor of significant stenosis, multivessel disease, and mixed plaques in women (all p < 0.05). UA was the only risk factor for mixed plaques in total (P = 0.046).ConclusionThe level of UA was significantly associated with coronary atherosclerosis in women, but not men.

【 授权许可】

Unknown   
© Sun et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.