Functional impairment related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a cross-sectional study

BMC Psychiatry

Research Article

Inmaculada Gilaberte¹  Irene Romera¹  Pepa Polavieja¹  Durisala Desaiah²  Ángel L Montejo³  José Arbesú⁴  Fernando Caballero⁵  Luis Caballero⁶ 

[1] Clinical Research Department, Lilly, SA, Avenida de la Industria, 30, 28108, Alcobendas, Spain;Consultant Scientific Communications and Training Lead, MCH - 92, Drop Code - 6122 Eli Lilly and Company, Lilly Corporate Center, 46285, Indianapolis, IN, USA;Hospital Universitario de Salamanca. School of Medicine, University of Salamanca, 37007, Salamanca, Spain;Primary Care Department, Centro de Salud de la Ería, 33013, Oviedo, Spain;Primary Care Research Department, 6th Health Area, Servicio Madrileño de Salud, 28020, Madrid, Spain;Psychiatry Department, Hospital Puerta de Hierro, 28222, Madrid, Spain;

关键词: Major Depressive Disorder;    Anxiety Disorder;    Functional Impairment;    Generalize Anxiety Disorder;    Pain Symptom;   

DOI  :  10.1186/1471-244X-11-69

 received in 2011-01-17, accepted in 2011-04-21,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundGeneralized anxiety disorder (GAD) is the most frequent anxiety disorder in primary care patients. It is known that painful physical symptoms (PPS) are associated with GAD, regardless the presence of comorbid major depressive disorder (MDD). However the specific role of such symptoms in patients' functional impairment is not well understood. The objective of the present study is to assess functional impairment related to the presence of PPS in patients with GAD.MethodsThis is a post hoc analysis of a cross-sectional study. Functioning, in the presence (overall pain score >30; Visual Analog Scale) or absence of PPS, was assessed using the Sheehan Disability Scale (SDS) in three groups of patients; 1) GAD and comorbid MDD (GAD+MDD+), 2) GAD without comorbid MDD (GAD+MDD-), 3) controls (GAD-MDD-). ANCOVA models were used.ResultsOf those patients with GAD+MDD+ (n = 559), 436 (78.0%) had PPS, compared with GAD+MDD- (249 of 422, 59%) and controls (95 of 336, 28.3%). Functioning worsened in both GAD groups in presence of PPS (SDS least squares mean total score: 16.1 vs. 9.8, p < 0.0001, GAD+MDD+; 14.3 vs. 8.2, p < 0.0001, GAD+MDD-). The presence of PPS was significantly associated with less productivity.ConclusionsFunctional impairment related to the presence of PPS was relevant. Clinical implications should be considered.

【 授权许可】

CC BY   
© Romera et al; licensee BioMed Central Ltd. 2011