Serotypes, seasonal trends, and antibiotic resistance of non-typhoidal Salmonella from human patients in Guangdong Province, China, 2009–2012

BMC Infectious Diseases

Research Article

Shuyu Wu¹  John D Klena²  Xiaoling Deng³  Qiong Huang³  Bixia Ke³  Lingling Lu³  Dongmei He³  Changwen Ke³  Junhua Liang³  Zhaoming Liang⁴  Zhongjie Li⁵  Lu Ran⁵  Hongjie Yu⁵ 

[1] China-US Collaborative Program on Emerging and Re-emerging Infectious Diseases, U.S. Center for Disease Control and Prevention, Beijing, China;China-US Collaborative Program on Emerging and Re-emerging Infectious Diseases, U.S. Center for Disease Control and Prevention, Beijing, China;Global Disease Detection Branch, Division of Global Health Protection, Center for Global Health, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA;Guangdong Provincial Centre for Disease Control and Prevention, Guangzhou, Guangdong, China;Guangdong Provincial Institute of Biological Products and Materia Medica, Guangzhou, Guangdong, China;Guangdong Provincial Centre for Disease Control and Prevention, Guangzhou, Guangdong, China;Office of Disease Control and Emergency Response, Chinese Center for Disease Control and Prevention, Beijing, China;

关键词: Cefotaxime;    Guangdong Province;    Nalidixic Acid;    Cefepime;    Antimicrobial Susceptibility Testing;   

DOI  :  10.1186/s12879-015-0784-4

 received in 2014-09-18, accepted in 2015-01-27,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundNon-typhoidal Salmonella is a common cause of infectious diarrhea in humans. Antimicrobial-resistant Salmonella has become a global concern.MethodsUsing laboratory-based surveillance system for Salmonella from September 2009 to December 2012 in Guangdong Province of China. The clinical information and samples of diarrhea patients were collected, according to the surveillance case definition. The lab tests were followed by standardized protocols, including sample isolation, isolates confirmation, serotyping, and antimicrobial susceptibility testing (AST).ResultsA total of 1,826 Salmonella isolates were identified from40,572 patients in 28 hospitals in11 prefectures. The isolates ratio was highest in autumn (38.8%, 708/1826) and lowest in winter (6.4%, 117/1826). Children aged <5 years were the group most affected by Salmonella in Guangdong Province accounting for 73% (1,329/1,826), of whom the infants (<1 year) were 81.5% (1084/1329) especially. A total of 108 serotypes were identified among the isolates. S. Typhimurium represented the most common serotype followed by serotype 4,5,12:i:-.S. Typhimurium was also the common serotype followed by S. Enteritidis among infants and children aged 1-3 years old. However, S. Enteritidis became the common serotype followed by S. Typhimurium among children aged 3–5 and >5 years.Resistance to at least one antimicrobial was found in 72% (1321/1,826) of the isolates. Resistance to at least three antimicrobials was found in 46% (850/1,826) of the isolates. Resistance to all 12 antimicrobials screened was observed in 8 isolates (0.44%, 8/1,826). The resistant prevalence to quinolones including nalidixic acid and ciprofloxacin was 61.9% (1131/1826), of which ciprofloxacin resistance rate was 8.05% (147/1826). The prevalence resistance to all three cephalosporin antimicrobials (cefepime, cefotaxime, and caftazidime) in <5 yr age group was accounted for 90% (89/99).ConclusionsAdditional data and more refined methods can improve future surveillance. The invasive Salmonella isolates should also be included to the antibiotic resistance surveillance for clinical care or public health.

【 授权许可】

Unknown   
© Liang et al.; licensee BioMed Central. 2015. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.