Micronucleus frequency in children exposed to biomass burning in the Brazilian Legal Amazon region: a control case study

BMC Oral Health

Research Article

Silvia Regina Batistuzzo de Medeiros¹  Paulo Artaxo²  Paulo HN Saldiva³  Sandra de Souza Hacon⁴  Herbert Ary Sisenando⁵ 

[1] Departamento de Biologia Celular e Genética, UFRN, Natal CEP: 59072-970, RN, Brazil;Departamento de Física Aplicada, USP São Paulo, CEP: 05508-900, SP, Brazil;Departamento de Patologia, USP, São Paulo, CEP: 01246-903, SP, Brazil;Escola Nacional de Saúde Pública - ENSP, Fiocruz, Rio de Janeiro CEP:, 21041-210, RJ, Brazil;Escola Nacional de Saúde Pública - ENSP, Fiocruz, Rio de Janeiro CEP:, 21041-210, RJ, Brazil;Departamento de Patologia, UFF, Niterói, CEP: 24033-900, RJ, Brazil;

关键词: Control Area;    Private School;    Biomass Burning;    Sugar Cane;    Buccal Cell;   

DOI  :  10.1186/1472-6831-12-6

 received in 2011-10-21, accepted in 2012-03-08,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundThe Amazon represents an area of 61% of Brazilian territory and is undergoing major changes resulting from disorderly economic development, especially the advance of agribusiness. Composition of the atmosphere is controlled by several natural and anthropogenic processes, and emission from biomass burning is one with the major impact on human health. The aim of this study was to evaluate genotoxic potential of air pollutants generated by biomass burning through micronucleus assay in exfoliated buccal cells of schoolchildren in the Brazilian Amazon region.MethodsThe study was conducted during the dry seasons in two regions of the Brazilian Amazon. The assay was carried out on buccal epithelial cells of 574 schoolchildren between 6-16 years old.ResultsThe results show a significant difference between micronucleus frequencies in children exposed to biomass burning compared to those in a control area.ConclusionsThe present study demonstrated that in situ biomonitoring using a sensitive and low cost assay (buccal micronucleus assay) may be an important tool for monitoring air quality in remote regions. It is difficult to attribute the increase in micronuclei frequency observed in our study to any specific toxic element integrated in the particulate matters. However, the contribution of the present study lies in the evidence that increased exposure to fine particulate matter generates an increased micronuclei frequency in oral epithelial cells of schoolchildren.

【 授权许可】

CC BY   
© Sisenando et al; licensee BioMed Central Ltd. 2012