Epidemiology of pertussis in two Ibero-American countries with different vaccination policies: lessons derived from different surveillance systems

BMC Public Health

Research Article

Rubén Solano¹  Ángela Domínguez²  Joan A. Caylà³  Altagracia Brache⁴  Zacarías Garib⁴  Patricia Grullón⁴  Sandy L. Santiago⁴  Josefa Masa-Calles⁵ 

[1] CIBER Epidemiology and Public Health (CIBERESP), Epidemiology Service-Barcelona Public Health Agency, Pl. Lesseps 1, 08023, Barcelona, Spain;Department of Public Health, University of Barcelona, Barcelona, Spain;Epidemiology Service, Barcelona Public Health Agency, Barcelona, Spain;Department of Public Health, University of Barcelona, Barcelona, Spain;CIBER Epidemiology and Public Health (CIBERESP), Epidemiology Service-Barcelona Public Health Agency, Pl. Lesseps 1, 08023, Barcelona, Spain;Epidemiology Service, Barcelona Public Health Agency, Barcelona, Spain;CIBER Epidemiology and Public Health (CIBERESP), Epidemiology Service-Barcelona Public Health Agency, Pl. Lesseps 1, 08023, Barcelona, Spain;Extended Immunizations Programme, Dominican Ministry of Health and Social Assistance, Santo Domingo, Dominican Republic;National Centre for Epidemiology, Carlos III Health Institute, Madrid, Spain;CIBER Epidemiology and Public Health (CIBERESP), Epidemiology Service-Barcelona Public Health Agency, Pl. Lesseps 1, 08023, Barcelona, Spain;

关键词: Bordetella pertussis;    Whooping cough;    Infectious disease epidemiology;    Surveillance;    Spain;    Dominican Republic;   

DOI  :  10.1186/s12889-016-3844-9

 received in 2016-06-15, accepted in 2016-11-15,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundPertussis is a re-emerging disease worldwide despite its high vaccination coverage. European and Latin-American countries have used different surveillance and vaccination policies against pertussis. We compared the epidemiology of this disease in two Ibero-American countries with different vaccination and surveillance policies.MethodsWe compared the epidemiology of pertussis in Spain and the Dominican Republic (DR). We present a 10-year observational study of reported pertussis based on suspected and/or probable cases of pertussis identified by the national mandatory reporting system in both countries between 2005 and 2014. Both countries have a similar case definition for pertussis surveillance, although Spain applies laboratory testing, and uses real time PCR and/or culture for case confirmation while in DR only probable and/or suspected cases are reported. We analyzed incidence, hospitalization, case-fatality rates, mortality and vaccination coverage.ResultsThe average annual incidence in children aged <1 year was 3.40/100,000 population in Spain and 12.15/100,000 in DR (p = 0.01). While the incidence in DR was generally higher than in Spain, in 2011 it was six times higher in Spain than in DR. The highest infant mortality in Spain was 0.017/100,000 in 2011, and the highest in DR was 0.08/100,000 in 2014 (p = 0.01). The proportion of hospitalized cases per year among children <1 year varied between 22.0% and 93.7% in Spain, and between 1.1% and 29.4% in DR (p = 0.0002), while mortality varied from 0 to 0.017 and 0 to 0.08 per 100,000 population in Spain and DR, respectively (p = 0.001). Vaccination coverage was 96.5% in Spain and 82.2% in DR (p = 0.001).ConclusionsPertussis is a public health problem in both countries. Surveillance, prevention and control measures should be improved, especially in DR. Current vaccination programs are not sufficient for preventing continued pertussis transmission, even in Spain which has high vaccination coverage.

【 授权许可】

CC BY   
© The Author(s). 2016