Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review

BMC Infectious Diseases

Research Article

Fatih Oguz Önder¹  Tanja Wörmann²  Gerard J Borsboom³  Joost van Rosmalen³  Jan Hendrik Richardus³  Mehlika Toy⁴  A Mithat Bozdayi⁵  Cihan Yurdaydin⁶  Solko W Schalm⁷ 

[1] Department of Gastroenterology, Yuksek Ihtisas Hospital, Kızılay Sk, 06100, Sıhhıye, Ankara, Turkey;Department of Public Health Medicine, School of Public Health, University of Bielefeld, Bielefeld, Northrhine-Westphalia, Germany;Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3000, Rotterdam, CA, The Netherlands;Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3000, Rotterdam, CA, The Netherlands;LiverDoc, Rotterdam, The Netherlands;Institute of Hepatology, Ankara University, Cemal Gursel caddesi, Ankara, Turkey;Institute of Hepatology, Ankara University, Cemal Gursel caddesi, Ankara, Turkey;Department of Gastroenterology, School of Medicine, Ankara University, Cemal Gursel caddesi, Ankara, Turkey;LiverDoc, Rotterdam, The Netherlands;Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3000 CA, Rotterdam, The Netherlands;

关键词: Health Care Worker;    Generalize Linear Mixed Model;    Military Recruit;    HBsAg Prevalence;    Military Conscript;   

DOI  :  10.1186/1471-2334-11-337

 received in 2011-04-20, accepted in 2011-12-12,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundTo provide a clear picture of the current hepatitis B situation, the authors performed a systematic review to estimate the age- and region-specific prevalence of chronic hepatitis B (CHB) in Turkey.MethodsA total of 339 studies with original data on the prevalence of hepatitis B surface antigen (HBsAg) in Turkey and published between 1999 and 2009 were identified through a search of electronic databases, by reviewing citations, and by writing to authors. After a critical assessment, the authors included 129 studies, divided into categories: 'age-specific'; 'region-specific'; and 'specific population group'. To account for the differences among the studies, a generalized linear mixed model was used to estimate the overall prevalence across all age groups and regions. For specific population groups, the authors calculated the weighted mean prevalence.ResultsThe estimated overall population prevalence was 4.57, 95% confidence interval (CI): 3.58, 5.76, and the estimated total number of CHB cases was about 3.3 million. The outcomes of the age-specific groups varied from 2.84, (95% CI: 2.60, 3.10) for the 0-14-yearolds to 6.36 (95% CI: 5.83, 6.90) in the 25-34-year-old group.ConclusionThere are large age-group and regional differences in CHB prevalence in Turkey, where CHB remains a serious health problem.

【 授权许可】

CC BY   
© Toy et al.; licensee BioMed Central Ltd. 2011